24242-74-8

Basic information

• Product Name: Acetic acid, (3,5-dimethylphenoxy)-, ethyl ester
• Synonyms: Ethyl 2-(3,5-dimethylphenyloxy) acetate;ethyl 2-(3,5-dimethylphenyloxy)-acetate;3,5-Dimethyl-phenoxyessigsaeure-ethylester;(3,5-dimethyl-phenoxy)-acetic acid ethyl ester;(3,5-Dimethyl-phenoxy)-essigsaeure-aethylester
• CAS NO: 24242-74-8
• Molecular Formula: C12H16O3
• Molecular Weight: 208.257
• Mol File: 24242-74-8.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Acetic acid, (3,5-dimethylphenoxy)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, (3,5-dimethylphenoxy)-, ethyl ester(24242-74-8)
• EPA Substance Registry System: Acetic acid, (3,5-dimethylphenoxy)-, ethyl ester(24242-74-8)

Safety Data

• Hazardous Substances Data: 24242-74-8(Hazardous Substances Data)

Upstream product

• 105-36-2 ethyl bromoacetate 
• 108-68-9 3,5-Dimethylphenol 
• 64-17-5 ethanol 
• 3926-62-3 sodium monochloroacetic acid 
• 37621-81-1 sodium 3,5-dimethylphenolate 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 99070-96-9 2-(4-(chlorosulfonyl)-3,5-dimethylphenoxy)acetic acid 
• 112122-57-3 N-{2-[(Z)-3-Chloro-phenylimino]-4-oxo-thiazolidin-3-yl}-2-(3,5-dimethyl-phenoxy)-acetamide 
• 112122-56-2 N-{2-[(Z)-4-Chloro-phenylimino]-4-oxo-thiazolidin-3-yl}-2-(3,5-dimethyl-phenoxy)-acetamide 
• 112122-59-5 2-(3,5-Dimethyl-phenoxy)-N-{4-oxo-2-[(Z)-p-tolylimino]-thiazolidin-3-yl}-acetamide 
• 112122-58-4 2-(3,5-Dimethyl-phenoxy)-N-{4-oxo-2-[(Z)-o-tolylimino]-thiazolidin-3-yl}-acetamide 
• 112122-55-1 2-(3,5-Dimethyl-phenoxy)-N-{4-oxo-2-[(Z)-phenylimino]-thiazolidin-3-yl}-acetamide 
• 103896-78-2 C₁₇H₁₈ClN₃O₂S 
• 103896-77-1 C₁₇H₁₈ClN₃O₂S 
• 112120-96-4 C₁₈H₂₁N₃O₂S 
• 112120-97-5 C₁₈H₂₁N₃O₂S 
• 103896-76-0 C₁₇H₁₉N₃O₂S 
• 5406-14-4 2-(3,5-dimethylphenoxy)acetic acid 
• 114305-86-1 3,5-Dimethyl-phenoxyacethydroxamsaeure 
• 83798-15-6 2-(3,5-dimethylphenoxy)acetohydrazide 

Relevant articles and documents

Expedient discovery for novel antifungal leads: 1,3,4-Oxadiazole derivatives bearing a quinazolin-4(3H)-one fragment

Developing novel fungicide candidates are intensively promoted by the rapid emergences of resistant fungi that outbreak on agricultural production. Aiming to discovery novel antifungal leads, a series of 1,3,4-oxadiazole derivatives bearing a quinazolin-4(3H)-one fragment were constructed for evaluating their inhibition effects against phytopathogenic fungi in vitro and in vivo. Systematically structural optimizations generated the bioactive molecule I32 that was identified as a promising inhibitor against Rhizoctonia solani with the in vivo preventative effect of 58.63% at 200 μg/mL. The observations that were captured by scanning electron microscopy and transmission electron microscopy demonstrated that the bioactive molecule I32 could induce the sprawling growth of hyphae, the local shrinkage and rupture on hyphal surfaces, the extreme swelling of vacuoles, the striking distortions on cell walls, and the reduction of mitochondria numbers. The above results provided an indispensable complement for the discovery of antifungal lead bearing a quinazolin-4(3H)-one and 1,3,4-oxadiazole fragment.

The synthesis and evaluation of phenoxyacylhydroxamic acids as potential agents for Helicobacter pylori infections

Two series of ω-phenoxy contained acylhydroxamic acids as novel urease inhibitors were designed and synthesized. Biological activity evaluations revealed that ω-phenoxypropinoylhydroxamic acids were more active than phenoxyacetohydroxamic acids. Out of these compounds, 3-(3,4-dichlorophenoxy)propionylhydroxamic acid c24 showed significant potency against urease in both cell free extract (IC50 = 0.061 ± 0.003 μM) and intact cell (IC50 = 0.89 ± 0.05 μM), being over 450- and 120-fold more potent than the clinically prescribed urease inhibitor AHA, repectively. Non-linear fitting of experimental data (V-[S]) suggested a mixed-type inhibition mechanism and a dual site binding mode of these compounds.

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