24246-07-9

Basic information

• Product Name: 1H-Pyrazole-3-acetic acid, 4,5-dihydro-5-oxo-1-phenyl-, methyl ester
• Synonyms: (5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-3-yl)-acetic acid methyl ester;methyl 2-(5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)acetate;HMS2721J14;HMS1551F12;methyl 2-(5-oxo-1-phenyl-2-pyrazolin-3-yl)acetate;methyl (5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)acetate
• CAS NO: 24246-07-9
• Molecular Formula: C12H12N2O3
• Molecular Weight: 232.239
• Mol File: 24246-07-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole-3-acetic acid, 4,5-dihydro-5-oxo-1-phenyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-3-acetic acid, 4,5-dihydro-5-oxo-1-phenyl-, methyl ester(24246-07-9)
• EPA Substance Registry System: 1H-Pyrazole-3-acetic acid, 4,5-dihydro-5-oxo-1-phenyl-, methyl ester(24246-07-9)

Safety Data

• Hazardous Substances Data: 24246-07-9(Hazardous Substances Data)

Usage

Molecular class

Pyrazole derivatives

Usage

Pharmaceutical industry (synthesis of various drugs and building block in organic synthesis)

Chemical structure

Pyrazole ring with a phenyl group and a methyl ester

Biological activities

Potential bioactive molecules synthesis starting material

Upstream product

• 1830-54-2 3-oxopentanedioic acid dimethyl ester 
• 100-63-0 phenylhydrazine 

Downstream Products

• 27316-52-5 methyl 2-(2-methyl-5-oxo-1-phenylpyrazole-3-yl)acetate 

Relevant articles and documents

PYRAZOLONE DERIVATIVE HAVING CYCLIC SIDE CHAIN

PROBLEM TO BE SOLVED: To provide a compound that has excellent inhibitory action on ATPase activity of TIP48/TIP49 complex and is therefore useful for the treatment of tumor, or a pharmacologically acceptable salt thereof. SOLUTION: The present invention provides a compound having a structure represented by general formula (I), its pharmacologically acceptable salt, or a pharmaceutical composition comprising the compound (where R1, R2, R3, R4, R5, R6, R7, W, and Z are as defined in the specifications). SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT

Transformations of alkyl (5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)acetates into 5-heteroaryl-3-oxo-2-phenyl-3,5-dihydro-2H-pyrazolo[4,3-c] pyridine-7-carboxylates

Alkyl [(Z)-4-dimethylaminomethylidene-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl] acetate (4) was transformed with N- and C-nucleophiles into alkyl [4-(substituted amino)methylidene-4,5-dihydro-1H-pyrazol-3- yl] acetates (7) and alkyl (4-heteroarylmethylidene-4,5-dihydro-1H -pyrazol-3-yl)acetates (8), respectively. Compounds (7) cyclize by heating with DMFDMA in DMF into 2H-pyrazolo[4,3-c]pyridine-7-carboxylates (9).