24246-87-5

Basic information

• Product Name: 1-(2-oxo-2-phenylethyl)-pyrrolidine-2,5-dione
• Synonyms: 1-(2-oxo-2-phenylethyl)-pyrrolidine-2,5-dione
• CAS NO: 24246-87-5
• Molecular Weight: 217.224
• Mol File: 24246-87-5.mol
• Article Data: 12

Chemical Properties

• Melting Point: 143-144 °C
• Boiling Point: 451.4±28.0 °C(Predicted)
• Density: 1.279±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-(2-oxo-2-phenylethyl)-pyrrolidine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-oxo-2-phenylethyl)-pyrrolidine-2,5-dione(24246-87-5)
• EPA Substance Registry System: 1-(2-oxo-2-phenylethyl)-pyrrolidine-2,5-dione(24246-87-5)

Safety Data

• Hazardous Substances Data: 24246-87-5(Hazardous Substances Data)

Usage

Chemical class

Pyrrolidine-2,5-diones

Molecular weight

217.22 g/mol

Usage

Flavoring agent and fragrance ingredient

Physical state

White crystalline solid

Melting point

107-109°C

Solubility

Soluble in ethanol and acetone

Biological activities

Potential for various biological activities and pharmacological properties

Research interest

Subject of interest for further research and development

Upstream product

• 123-56-8 Succinimide 
• 70-11-1 α-bromoacetophenone 
• 536-74-3 phenylacetylene 
• 128-08-5 N-Bromosuccinimide 
• 100-42-5 styrene 
• 50433-20-0 potassium succinimide 
• 532-27-4 1-chloroacetophenone 
• 1313233-02-1 C₁₂H₉NO₂ 
• 98-86-2 acetophenone 
• 108-30-5 succinic acid anhydride 
• 5468-37-1 2-aminoacetophenone hydrochloride 
• 1174150-89-0 (E)-4-oxo-N-(2-oxo-2-phenylethyl)but-2-enamide 
• 98-88-4 benzoyl chloride 
• 43003-15-2 N-(2-phenyl-2-oxoethyl)-2-pyrrolidinone 

Downstream Products

• 613-89-8 2-Aminoacetophenone 

Relevant articles and documents

A facile transformation of alkynes into α-amino ketones by an N-bromosuccinimide-mediated one-pot strategy

A facile transformation of alkynes into α-amino ketones by an N-bromosuccinimide-mediated one-pot cascade strategy is described. A variety of α-amino ketones are obtained in moderate to good yields under mild conditions. To overcome the multi-step synthesis, N-bromosuccinimide is involved in multiple tasks, playing a key role in the reaction course.

Regioselective oxo-amination of alkenes and enol ethers with N-bromosuccinimide-dimethyl sulfoxide combination: A facile synthesis of α-amino-ketones and esters

An unprecedented conversion of alkenes and enol ethers to the corresponding α-imido carbonyl compounds with excellent regioselectivity and yields has been developed. This oxo-amination process employs readily available N-bromosuccinimide (NBS) and secondary amines as N-sources and dimethyl sulfoxide (DMSO) as the oxidant and also leads to the production of amino alcohols in a single step on reduction, thus broadening the scope of this operationally simple reaction. For the first time, the formation of reactive Me2S+-O-Br species generated by the interaction of NBS with DMSO has been proven.

N-Heterocyclic Carbene Catalyzed Oxidative Coupling of Alkenes/ α-Bromoacetophenones with Aldehydes: A Facile Entry to α,β-Epoxy Ketones

A novel, N-heterocyclic carbene (NHC) catalyzed direct oxidative coupling of styrenes with aldehydes has been described for the synthesis of α,β-epoxy ketones in good yields. This unprecedented regioselective oxidative coupling employs NBS/DBU/DMSO (DBU=1,8-diazabicyclo [5.4. 0] undec-7-ene, DMSO=dimethylsulfoxide, NBS=N-bromosuccinimide) as an oxidative system at ambient conditions. Additionally, first NHC-catalyzed Darzens reaction of α-bromoketones and aldehydes under mild reaction conditions has also been described. Interestingly, mechanistic studies have revealed the preferred reactivity of NHC with alkene/α-bromoketone rather than aldehydes, thus proceeding via the ketodeoxy Breslow intermediate.