24248-48-4

Basic information

• Product Name: ethyl 3-(4,5-diphenyloxazol-2-yl)propanoate
• Synonyms: ethyl 3-(4,5-diphenyloxazol-2-yl)propanoate
• CAS NO: 24248-48-4
• Molecular Weight: 321.376
• Mol File: 24248-48-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 3-(4,5-diphenyloxazol-2-yl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-(4,5-diphenyloxazol-2-yl)propanoate(24248-48-4)
• EPA Substance Registry System: ethyl 3-(4,5-diphenyloxazol-2-yl)propanoate(24248-48-4)

Safety Data

• Hazardous Substances Data: 24248-48-4(Hazardous Substances Data)

Downstream Products

• 21256-18-8 3-(4,5-Diphenyl-oxazol-2-yl)-propionic acid 

Relevant articles and documents

Synthesis of Extended Oxazoles III: Reactions of 2-(Phenylsulfonyl)methyl-4,5-diaryloxazoles

2-((Phenylsulfonyl)methyl)-4,5-diphenyloxazole is a useful scaffold for synthetic elaboration at the 2-methylene position thereby affording extended oxazoles. The corresponding α-sulfonyl anion reacts smoothly with diverse alkyl halides giving monoalkylated (47-90%), dialkylated (50-97%), and cyclic (59-93%) products. The reductive desulfonylation of the monoalkylated and selected dialkylated products was optimized with a magnesium/mercuric chloride reagent system and afforded desulfonylated products in the range of 66-97%. The anti-inflammatory Oxaprozin was prepared using the α-sulfonyl carbanion strategy along with optimized desulfonylation.