24279-39-8

Basic information

• Product Name: 4-Amino-3,5-dichlorobenzotrifluoride
• Synonyms: 3,5-DICHLORO-4-AMINO BENZOTRIFLUORIDE;2,6-DICHLORO-4-(TRIFLUOROMETHYL)ANILINE;BUTTPARK 29\06-100;TIMTEC-BB SBB003283;2,6-dichloro-4-Trifluoromethyllaniline;4-Amino-3,5-dichlorobenzotrifluoride,97% (2,6-Dichloro-4-trifluoromethylaniline);2,6-dichloro-(trifluoromethyl)aniline;2,6-Dichloro-4-(trifluoromethyl)aniline 99%
• CAS NO: 24279-39-8
• Molecular Formula: C₇H₄Cl₂F₃N
• Molecular Weight: 230.01
• EINECS: 416-430-0
• Product Categories: Trifluoromethylbenzene serise;Anilines, Aromatic Amines and Nitro Compounds;Aromatic Halides (substituted);Aniline;Fluorochemicals;API intermediates;Pesticide Intermediate;Benzenes;Amines;C7;Nitrogen Compounds;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;amine| alkyl chloride
• Mol File: 24279-39-8.mol
• Article Data: 18

Chemical Properties

• Melting Point: 34-36 °C(lit.)
• Boiling Point: 60-62 °C1 mm Hg(lit.)
• Flash Point: 190 °F
• Appearance: light yellow low melting crystalline mass
• Density: 1.532 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.241mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: soluble in Methanol
• PKA: -1.13±0.10(Predicted)
• BRN: 2838819
• CAS DataBase Reference: 4-Amino-3,5-dichlorobenzotrifluoride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-3,5-dichlorobenzotrifluoride(24279-39-8)
• EPA Substance Registry System: 4-Amino-3,5-dichlorobenzotrifluoride(24279-39-8)

Safety Data

• Hazard Codes: Xn,N,T
• Statements: 20/22-38-43-50/53
• Safety Statements: 24-37-60-61
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 3
• HazardClass: TOXIC
• PackingGroup: III
• Hazardous Substances Data: 24279-39-8(Hazardous Substances Data)

Usage

Description

4-Amino-3,5-dichlorobenzotrifluoride is an organic compound characterized by its amino group attached to a benzene ring, which is substituted with two chlorine atoms at the 3rd and 5th positions, and a trifluoromethyl group at the 4th position. 4-Amino-3,5-dichlorobenzotrifluoride is known for its reactivity and is commonly utilized in the synthesis of various pharmaceuticals and agrochemicals due to its unique structural features.

Uses

Used in Pharmaceutical Industry:
4-Amino-3,5-dichlorobenzotrifluoride is used as an intermediate in the synthesis of GABA receptor antagonists. It plays a crucial role in the development of medications targeting neurological disorders by modulating the activity of GABA receptors in the brain.
Used in Agrochemical Industry:
4-Amino-3,5-dichlorobenzotrifluoride is used as a key component in the production of insecticides. Its chemical structure allows for the creation of compounds that can effectively control and manage insect populations, thereby protecting crops and reducing agricultural losses.
Used in Organic Synthesis:
4-Amino-3,5-dichlorobenzotrifluoride may be employed for the synthesis of complex organic molecules, such as 1-[2,6-di-chloro-4-(tri-fluoro-methyl)-phenyl]-5-[(4-nitro-phenyl)-methyl-ene-imino]-1H-pyrazole-3-carbo-nitrile. 4-Amino-3,5-dichlorobenzotrifluoride has potential applications in various fields, including pharmaceuticals and materials science, due to its unique chemical properties and reactivity.

preparation

Using 4-chlorotrifluoromethylbenzene as raw material, 2,6-dichloro-4-trifluoromethylaniline was prepared through two-step reaction of amination and chlorination.

InChI:InChI=1/C7H4Cl2F3N/c8-4-1-3(7(10,11)12)2-5(9)6(4)13/h1-2H,13H2

Upstream product

• 2926-29-6 Langlois reagent 
• 608-31-1 2,6-Dichloroaniline 
• 455-14-1 4-trifluoromethylphenylamine 
• 57729-79-0 2-chloro-6-nitro-4-(trifluoromethyl)aniline 
• 56148-83-5 2,4,5-trichloro-1-(trifluoromethyl)benzene 
• 5216-25-1 4-chlorotrichloromethylbenzene 
• 106-43-4 para-chlorotoluene 
• 156639-47-3 2,6-dichloro-4-trifluoromethyl-N-methylaniline 
• 689300-85-4 (2-chloro-4-trifluoromethyl-phenyl)-methyl-amine 
• 328-84-7 1,2-dichloro-4-(trifluoromethyl)benzene 
• 39885-50-2 2-chloro-4-(trifluoromethyl)aniline 
• 2314-97-8 iodotrifluoromethane 
• 50594-82-6 1-trifluoromethyl-3,4,5-trichlorobenzene 
• 86398-94-9 2,6-dichloro-4-(trifluoromethyl)phenyl hydrazine 

Downstream Products

• 133152-04-2 2-azido-1,3-dichloro-5-(trifluoromethyl)benzene 
• 120068-79-3 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole 
• 68105-63-5 (2,6-Dichloro-4-trifluoromethyl-phenyl)-(2,4-dinitro-naphthalen-1-yl)-amine 
• 213132-03-7 2-(2, 6-Dichloro-4-trifluoromethylphenylhydrazono)succinonitrile 

Relevant articles and documents

New synthesis method of 2,6-dichloro-4-trifluoromethylaniline

The invention discloses a new synthesis method of 2,6-dichloro-4-trifluoromethylaniline, wherein p-trifluoromethylaniline is usedas a raw material, and is added with a certain amount of sulfonyl chloride in a dropwise manner, and chlorination, water washing and pressure reducing rectification are performed to obtain the target compound. Compared with the method in the prior art, the method of theinvention has characteristics of simple process, easy operation, short reaction time, high yield and low production cost, is suitable for industrial production, is an environmentally-friendly chemicalprocess, and has good industrial application prospect.

A process for preparing 3, 4, 5 - toluene azeotrope by-product of the 2, 4, 5 - method for comprehensive utilization of toluene azeotrope (by machine translation)

A process for preparing 3, 4, 5 - toluene azeotrope by-product of the 2, 4, 5 - method for comprehensive utilization of toluene azeotrope, which belongs to the field of chemical synthesis. In order to 2, 4, 5 - trifluoro toluene as the raw materials, the aminolysis reaction, catalytic hydrogenation dechlorination reaction, the chlorination reaction to synthesize 2, 6 - dichloro - 4 - trifluoromethyl aniline. The above-mentioned integrated utilization method, the useless by-product into higher economic value products, the overall yield 61.7%, purity of 99.5% or more, less impurity species, product quality and stable performance. (by machine translation)

2,6-dichloro-4-trifluoromethyl phenylamine chlorine flow production process

The invention relates to a 2,6-dichloro-4-trifluoromethyl phenylamine chlorine flow production process. According to the method, 2-chloro-4-trifluoromethyl-N,N-dimethylaniline is used as raw materials; 2,6-dichloro-4-trifluoromethyl phenylamine is directly prepared through chlorine gas chlorination. The technological process is simple; the single reaction quantity is increased and is twice of the original quantity; the reaction is mild; side reactions are few; the operation is simple and easy to control; the conversion rate is high; the content reaches 80 percent; chlorine gas is absorbed to obtain HCl for other production; the environment pollution cannot be caused; the environment-friendly effect is good.