24285-73-2

Basic information

• Product Name: 2-(4-chlorophenyl)-5-phenyl-1,3-oxazole
• Synonyms: oxazole, 2-(4-chlorophenyl)-5-phenyl-
• CAS NO: 24285-73-2
• Molecular Formula: C₁₅H₁₀ClNO
• Molecular Weight: 255.699
• Mol File: 24285-73-2.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 410.4°C at 760 mmHg
• Flash Point: 202°C
• Density: 1.229g/cm³
• Vapor Pressure: 1.43E-06mmHg at 25°C
• Refractive Index: 1.595
• CAS DataBase Reference: 2-(4-chlorophenyl)-5-phenyl-1,3-oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenyl)-5-phenyl-1,3-oxazole(24285-73-2)
• EPA Substance Registry System: 2-(4-chlorophenyl)-5-phenyl-1,3-oxazole(24285-73-2)

Safety Data

• Hazardous Substances Data: 24285-73-2(Hazardous Substances Data)

Usage

Type of compound

Heterocyclic compound

Elements present

Oxygen and nitrogen atoms

Ring structure

Five-membered ring

Usage

Organic synthesis and medicinal chemistry

Biological activities

Exhibits various activities

Role in drug development

Acts as a pharmacophore in designing antitumor agents and developing potential pharmaceutical drugs

Suitability

Ideal for further exploration in drug discovery and development due to its chemical structure and properties

Upstream product

• 400076-37-1 N-tert-pentanoyloxy-p-chlorobenzamide 
• 536-74-3 phenylacetylene 
• 1006-68-4 5-phenyloxazole 
• 637-87-6 1-Chloro-4-iodobenzene 
• 39887-24-6 N-(2-phenylethyl)-p-chlorobenzamide 
• 104-86-9 4-chlorobenzylamine 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 3848-36-0 4-chlorobenzaldoxime 
• 70-11-1 α-bromoacetophenone 
• 101854-87-9 trans-2-benzoyl-3-(4-chlorophenyl)aziridine 
• 98-86-2 acetophenone 
• 1074-12-0 phenylglyoxal hydrate 
• 1075-06-5 2,2-dihydroxy-1-phenyl-ethanone 
• 122-78-1 phenylacetaldehyde 

Downstream Products

• 93-89-0 benzoic acid ethyl ester 
• 7335-27-5 ethyl 4-chlorobenzoate 
• 65-85-0 benzoic acid 
• 74-11-3 para-chlorobenzoic acid 

Relevant articles and documents

Photoinduced Heterogeneous C?H Arylation by a Reusable Hybrid Copper Catalyst

Heterogeneous copper catalysis enabled photoinduced C?H arylations under exceedingly mild conditions at room temperature. The versatile hybrid copper catalyst provided step-economical access to arylated heteroarenes, terpenes and alkaloid natural products with various aryl halides. The hybrid copper catalyst could be reused without significant loss of catalytic efficacy. Detailed studies in terms of TEM, HRTEM and XPS analysis of the hybrid copper catalyst, among others, supported its outstanding stability and reusability.

CO2/Photoredox-Cocatalyzed Tandem Oxidative Cyclization of α-Bromo Ketones and Amines to Construct Substituted Oxazoles

CO2/photoredox-cocatalyzed tandem oxidative cyclization of α-bromo ketones and amines for the preparation of substituted oxazoles has been achieved. The avoidance of using both transition-metal catalysts and peroxides makes this method more sustainable and renewable.

Photoinduced Copper-Catalyzed C-H Arylation at Room Temperature

Room-temperature azole C-H arylations were accomplished with inexpensive copper(I) compounds by means of photoinduced catalysis. The expedient copper catalysis set the stage for site-selective C-H arylations of non-aromatic oxazolines under mild reaction conditions, and provides step-economical access to the alkaloid natural products balsoxin and texamine. Copper light: Room-temperature C-H arylations of heteroarenes were accomplished with inexpensive copper compounds by photoinduced catalysis. The expedient copper catalysis leads to site-selective C-H arylations of non-aromatic oxazolines under mild reaction conditions, and provides step-economical access to the alkaloid natural products balsoxin and texamine.