243-51-6

Basic information

• Product Name: 11H-indeno[1,2-b]quinoline
• Synonyms: 11H-Indeno(1,2-b)quinoline; NSC 150251
• CAS NO: 243-51-6
• Molecular Formula: C₁₆H₁₁N
• Molecular Weight: 217.2652
• EINECS: 205-958-5
• Mol File: 243-51-6.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 410.6°C at 760 mmHg
• Flash Point: 184.2°C
• Density: 1.236g/cm³
• Vapor Pressure: 1.42E-06mmHg at 25°C
• Refractive Index: 1.724
• CAS DataBase Reference: 11H-indeno[1,2-b]quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 11H-indeno[1,2-b]quinoline(243-51-6)
• EPA Substance Registry System: 11H-indeno[1,2-b]quinoline(243-51-6)

Safety Data

• Hazardous Substances Data: 243-51-6(Hazardous Substances Data)

Usage

General Description

11H-Indeno[1,2-b]quinoline, also known as 11H-Indenoquinoline, is a polycyclic aromatic hydrocarbon (PAH) that exhibits anti-neoplastic and anti-inflammatory properties. It has been identified as a potent inhibitor of DNA topoisomerase II, an enzyme involved in the unwinding and rewinding of DNA during replication and transcription. Additionally, it has been studied for its potential use in cancer therapy due to its ability to induce apoptosis and inhibit cell growth. However, 11H-Indenoquinoline is also considered a mutagen and a potential carcinogen, as prolonged exposure to this chemical has been linked to DNA damage and tumor formation. Therefore, its use and handling should be approached with caution and proper safety measures to minimize the risks associated with its potential hazardous effects.

Upstream product

• 611-32-5 8-methylquinoline 
• 95-46-5 2-methylphenyl bromide 
• 98030-19-4 11H-indeno[1,2-b]quinoline-10-carboxylic acid 
• 6626-66-0 10H-indeno[1,2-b]quinolin-10-one 
• 5344-90-1 2-Aminobenzyl alcohol 
• 6351-10-6 1-Indanol 
• 51813-43-5 (E)-2-(2-aminobenzylidene)-2,3-dihydro-1H-inden-1-one 
• 16714-25-3 2-azidobenzaldehyde 
• 83-33-0 inden-1-one 
• 4403-69-4 2-amino-1-benzylamine 
• 552-89-6 2-nitro-benzaldehyde 
• 529-23-7 o-aminobenzaldehyde 
• 879721-09-2 2-phenyl-quinoline-3-carbonyl chloride 
• 74812-71-8 1-Chloro-3H-indene-2-carboxaldehyde 

Downstream Products

• 6626-66-0 10H-indeno[1,2-b]quinolin-10-one 
• 612-96-4 2-Phenylquinoline 
• 6626-65-9 11H-indeno<1,2-b>quinolin-11-ol 
• 124-38-9 carbon dioxide 
• 133348-05-7 2-phenylquinoline-3-carboxylic acid 
• 170954-08-2 2-[2]quinolyl-benzoic acid 

Relevant articles and documents

Pincerlike manganese complex and preparation method thereof, related ligand and preparation method thereof, catalyst composition and application

The invention discloses a pincerlike manganese complex, a preparation method thereof, a ligand for preparation, a preparation method of the ligand, a catalyst composition taking the complex as an active component and application of the catalyst composition. According to the pincerlike manganese complex, a cycloalkyl ring is introduced into a ligand framework, and by regulating and controlling the cyclic tension, flexibility and steric hindrance of the cycloalkyl ring, the reactivity and stability of the manganese metal center can be effectively adjusted, and the catalytic activity and substrate applicability of a manganese metal system are remarkably improved. The catalyst composition taking the pincerlike manganese complex as an active component has the advantages of high catalyst activity, wide substrate application range, mild reaction conditions and the like in the process of preparing quinoline or pyridine derivatives by catalyzing dehydrogenation coupling reaction of o-amino aromatic alcohol or gamma-amino alcohol, ketone or secondary alcohol; and the synthesis advantages of low cost and stable performance are embodied, the operation is simple, and the yield is high.

OLIGOAZAFLUORENE MONOMER

PROBLEM TO BE SOLVED: To provide an oligoazafluorene monomer that exhibits optical properties, heat resistance, thermal stability and good solubility. SOLUTION: The oligoazafluorene monomer is represented by the general formula (1) in the figure. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT

Phosphine-Free NNN-Manganese Complex Catalyzed α-Alkylation of Ketones with Primary Alcohols and Friedl?nder Quinoline Synthesis

Herein, we report a very simple and inexpensive catalytic system based on Earth's abundant transition metal manganese and on a bench-stable phosphine-free NNN-pincer ligand for an atom-efficient α-alkylations of ketones with primary alcohols via hydrogen-autotransfer C?C bond formation protocol. The precatalyst could be generated in situ and could be activated by using catalytic amount of base under milder conditions. A range of ketones were efficiently diversified with a broad range of primary alcohols in good to excellent isolated yields. Remarkably, this catalyst could also be employed for the synthesis of quinoline derivatives using 2-aminobenzyl alcohol as an alkylating agent. The later reaction is highly benign producing only hydrogen and water as byproducts. (Figure presented.).