2430-99-1

Basic information

• Product Name: 2-(4-METHYLPHENYL)ACETOPHENONE
• Synonyms: 4-METHYLBENZYL PHENYL KETONE;2-(4-METHYLPHENYL)ACETOPHENONE;2-(P-TOLYL)ACETOPHENONE;P-TOLYLMETHYL PHENYL KETONE;4-METHYLBENZYL PHENYL KETONE 95+% GC;2-(4-methylphenyl)-1-phenylethanone;2-(4-methylphenyl)-1-phenyl-ethanone;Ethanone, 2-(4-Methylphenyl)-1-phenyl-
• CAS NO: 2430-99-1
• Molecular Formula: C₁₅H₁₄O
• Molecular Weight: 210.27
• Mol File: 2430-99-1.mol
• Article Data: 59

Chemical Properties

• Melting Point: 95 °C
• Boiling Point: 155 °C / 2mmHg
• Flash Point: 145 °C
• Appearance: /
• Density: 1.062 g/cm³
• Vapor Pressure: 0.000102mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-(4-METHYLPHENYL)ACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-METHYLPHENYL)ACETOPHENONE(2430-99-1)
• EPA Substance Registry System: 2-(4-METHYLPHENYL)ACETOPHENONE(2430-99-1)

Safety Data

• Hazardous Substances Data: 2430-99-1(Hazardous Substances Data)

Usage

General Description

2-(4-Methylphenyl)acetophenone, also known as 4'-Methylacetophenone, is an organic compound with the chemical formula C16H16O. It is a ketone and a derivative of acetophenone, with a methyl group attached to the phenyl ring. This chemical is commonly used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It is a white solid with a melting point of 76-78°C and has a slightly sweet, floral aroma. Its versatility and reactivity make it a valuable intermediate in organic synthesis.

InChI:InChI=1/C15H14O/c1-12-7-9-13(10-8-12)11-15(16)14-5-3-2-4-6-14/h2-10H,11H2,1H3

Upstream product

• 22440-35-3 2-phenyl-3-p-tolyl-oxirane 
• 5435-44-9 (E)-3-Ureido-but-2-enoic acid ethyl ester 
• 14538-45-5 2-(4-methylphenoxy)acetophenone 
• 104-87-0 4-methyl-benzaldehyde 
• 100-47-0 benzonitrile 
• 104-85-8 para-methylbenzonitrile 
• 25726-04-9 phenylglyoxylyl chloride 
• 104-82-5 4-Methylbenzyl chloride 
• 7446-70-0 aluminium trichloride 
• 70-11-1 α-bromoacetophenone 
• 108-88-3 toluene 
• 40739-81-9 p-tolualdehyde p-toluenesulfonylhydrazone 
• 100-52-7 benzaldehyde 
• 83283-99-2 triphenylphosphonium-chlorid 

Downstream Products

• 40491-23-4 1,1-diphenyl-2-p-tolyl-ethanol 
• 20498-68-4 1-phenyl-2-(4-methylphenyl)ethanol 
• 132981-94-3 4-phenyl-5-(p-tolyl)thiazol-2-amine 
• 71472-48-5 3-phenyl-4-p-tolyl-[1,2,5]thiadiazole 
• 142438-13-9 3-tolyl-2,4,5-triphenylpyrrole 
• 96633-39-5 3-phenyl-4-p-tolyl-5,5-dimethyl-2-cyclohexen-1-one 
• 96633-38-4 1-phenyl-2-p-tolyl-3,3-dimethyl-1,5-hexanedione 
• 142438-11-7 1,3-diphenyl-2-tolyl-1,4-pentanedione 
• 36414-60-5 2-bromo-1-phenyl-2-(p-tolyl)ethan-1-one 
• 15830-84-9 α-p-Tolyl-β-phenyl-acrylphenon 
• 14271-33-1 2-methyl-1-phenyl-2-(4-methylphenyl)propan-1-one 
• 28150-10-9 1-Phenyl-2-p-tolyl-butan-1-ol 
• 31464-78-5 2-{[2-Oxo-2-phenyl-1-p-tolyl-eth-(E)-ylidene]-hydrazono}-1-phenyl-2-p-tolyl-ethanone 
• 4830-30-2 Benzoyl-(4-methyl-phenyl)-diazomethan 

Relevant articles and documents

H2O2-mediated room temperature synthesis of 2-arylacetophenones from arylhydrazines and vinyl azides in water

An environmentally benign, cost-efficient and practical methodology for the room temperature synthesis of 2-arylacetophenones in water has been discovered. The facile and efficient transformation involves the oxidative radical addition of arylhydrazines with α-aryl vinyl azides in the presence of H2O2 (as a radical initiator) and PEG-800 (as a phase-transfer catalyst). From the viewpoint of green chemistry and organic synthesis, the present protocol is of great significance because of using cheap, non-toxic and readily available starting materials and reagents as well as amenability to gram-scale synthesis, which provides an attractive strategy to access 2-arylacetophenones.

The organocatalytic enantiodivergent fluorination of β-ketodiaryl-phosphine oxides for the construction of carbon-fluorine quaternary stereocenters

Commercially available cinchona alkaloids that can catalyze the enantiodivergent fluorination of β-ketodiarylphosphine oxides were developed to construct carbon-fluorine quaternary stereocenters. This protocol features a wide scope of substrates and excellent enantioselectivities, and it is scalable.

Palladium-catalyzed synthesis of α-aryl acetophenones from styryl ethers and aryl diazonium saltsviaregioselective Heck arylation at room temperature

Preparation of α-aryl acetophenones from styryl ethers and aryldiazonium salts is described. The reaction is catalyzed by palladium acetate at room temperature in the absence of ligand and base. The developed method is highly attractive in terms of reaction conditions, substrate scope, functional group tolerance and yields. Synthetic applications of the present method are demonstrated by preparing α-aryl indoles and 3-aryl isocoumarin from styryl ethers.