24303-64-8

Basic information

• Product Name: 4-Methoxy-but-2-ynoic acid
• Synonyms: 4-Methoxy-but-2-ynoic acid;4-methoxy-2-Butynoic acid
• CAS NO: 24303-64-8
• Molecular Formula: C₅H₆O₃
• Molecular Weight: 114.09934
• Mol File: 24303-64-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 114-118 °C(Press: 3 Torr)
• Appearance: /
• Density: 1.196±0.06 g/cm3(Predicted)
• PKA: 2.10±0.10(Predicted)
• CAS DataBase Reference: 4-Methoxy-but-2-ynoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxy-but-2-ynoic acid(24303-64-8)
• EPA Substance Registry System: 4-Methoxy-but-2-ynoic acid(24303-64-8)

Safety Data

• Hazardous Substances Data: 24303-64-8(Hazardous Substances Data)

Usage

General Description

4-Methoxy-but-2-ynoic acid is a chemical compound with the molecular formula C6H8O3. It is a derivative of butynoic acid, containing a methoxy group (-OCH3) attached to the carbon atom in the fourth position of the butynoic acid chain. 4-Methoxy-but-2-ynoic acid is a carboxylic acid, which means it contains a carboxyl group (-COOH) and is therefore acidic in nature. It is often used as a building block in organic synthesis and can be utilized in the production of pharmaceuticals, agrochemicals, and other chemical products. Additionally, 4-Methoxy-but-2-ynoic acid may have potential applications in the field of medicinal chemistry due to its structural properties and potential biological activities.

Upstream product

• 676-58-4 methylmagnesium chloride 
• 627-41-8 propargyl alcohol methyl ether 
• 124-38-9 carbon dioxide 

Downstream Products

• 214485-51-5 N-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-6-quinolinyl}-4-methoxy-2-butynamide 
• 1431958-84-7 C₂₁H₂₁N₅O₂S 

Relevant articles and documents

Carboxylation of Terminal Alkynes with Carbon Dioxide Catalyzed by an In Situ Ag2O/N-Heterocyclic Carbene Precursor System

A carboxylation of terminal alkynes with carbon dioxide (CO2) at ambient conditions was developed in situ using a series of N-heterocyclic carbene (NHC) precursors and Ag2O. The unique structure of NHCs largely increases the solubility of active Ag species and meanwhile activates CO2 by forming the NHC–CO2 adduct. This novel catalytic system demonstrated quite low Ag loading, very high activities, wide substrate generality and excellent tolerance for a variety of functionalities. In addition, avoiding cumbersome synthesis procedures, processing, and reserving of the photosensitive Ag complex, this system could be stored and operated as straightforward as the inorganic Ag salt catalysts.

OXAZOLIDINONE HYDROXAMIC ACID COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS

This invention pertains generally to treating bacterial infections using organic compounds of Formula I. In certain aspects, the invention pertains to treating infections caused by Gram-negative bacteria. (I) wherein X, Y, R1, R2, R3, R4 and R5 and defined herein.

4 - IMIDAZOPYRIDAZIN- 1 -YL-BENZAMIDES AND 4 - IMIDAZOTRIAZIN- 1 - YL - BENZAMIDES AS BTK- INHIBITORS

The present invention relates to 6-5 membered fused pyridine ring compounds according to formula (I) or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of 6-5 membered fused pyridine ring compounds according to formula I in the treatment of Brutons Tyrosine Kinase (Btk) mediated disorders.