24318-44-3Relevant articles and documents
Cu(ii)-catalyzed esterification reaction via aerobic oxidative cleavage of C(CO)-C(alkyl) bonds
Ma, Ran,He, Liang-Nian,Liu, An-Hua,Song, Qing-Wen
, p. 2145 - 2148 (2016)
A novel Cu(ii)-catalyzed aerobic oxidative esterification of simple ketones for the synthesis of esters has been developed with wide functional group tolerance. This process is assumed to go through a tandem sequence consisting of α-oxygenation/esterification/nucleophilic addition/C-C bond cleavage and carbon dioxide is released as the only byproduct.
Flow chemistry as a discovery tool to access sp2-sp3 cross-coupling reactions via diazo compounds
Tran, Duc N.,Battilocchio, Claudio,Lou, Shing-Bong,Hawkins, Joel M.,Ley, Steven V.
, p. 1120 - 1125 (2015/03/04)
The work takes advantage of an important feature of flow chemistry, whereby the generation of a transient species (or reactive intermediate) can be followed by a transfer step into another chemical environment, before the intermediate is reacted with a coupling partner. This concept is successfully applied to achieve a room temperature sp2-sp3 cross coupling of boronic acids with diazo compounds, these latter species being generated from hydrazones under flow conditions using MnO2 as the oxidant.
Cu-catalyzed esterification reaction via aerobic oxygenation and C-C bond cleavage: An approach to α-ketoesters
Zhang, Chun,Feng, Peng,Jiao, Ning
supporting information, p. 15257 - 15262 (2013/11/06)
The Cu-catalyzed novel aerobic oxidative esterification reaction of 1,3-diones for the synthesis of α-ketoesters has been developed. This method combines C-C σ-bond cleavage, dioxygen activation and oxidative C-H bond functionalization, as well as provides a practical, neutral, and mild synthetic approach to α-ketoesters which are important units in many biologically active compounds and useful precursors in a variety of functional group transformations. A plausible radical process is proposed on the basis of mechanistic studies.
