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2434-53-9

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2434-53-9 Usage

Description

6-Amino-1-methyluracil is an amino derivative of uracil, a crystalline powder that ranges from almost white to slightly beige in color. It has been evaluated for its standard molar enthalpy of combustion and is known for its host-guest complexation with tetrapropoxycalix[4]arene.

Uses

Used in Pharmaceutical Applications:
6-Amino-1-methyluracil is used as an inhibitor for DNA repair glycosylase, playing a role in the development of pharmaceuticals that target DNA repair mechanisms.
Used in Chemical Synthesis:
6-Amino-1-methyluracil is used as a chemical intermediate in the preparation of complex organic compounds, such as 1,1'-di methyl-1H-spiro[pyrimido[4,5-b]quinoline-5,5'-pyrrolo[2,3-d]pyrimidine]-2,2',4,4',6'(1'H,3'H,3'H,7'H,1'H)-pentaone, via a reaction with isatin in the presence of catalytic p-toluene sulfonic acid.
Used in Flame Retardancy:
6-Amino-1-methyluracil is also utilized as a component in the flame retardant industry, where it contributes to the development of materials with enhanced fire-resistant properties.

Check Digit Verification of cas no

The CAS Registry Mumber 2434-53-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,4,3 and 4 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2434-53:
(6*2)+(5*4)+(4*3)+(3*4)+(2*5)+(1*3)=69
69 % 10 = 9
So 2434-53-9 is a valid CAS Registry Number.
InChI:InChI=1/C5H7N3O2/c1-8-3(6)2-4(9)7-5(8)10/h2H,6H2,1H3,(H,7,9,10)

2434-53-9 Well-known Company Product Price

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  • TCI America

  • (A2449)  6-Amino-1-methyluracil  >98.0%(HPLC)(T)

  • 2434-53-9

  • 5g

  • 360.00CNY

  • Detail
  • TCI America

  • (A2449)  6-Amino-1-methyluracil  >98.0%(HPLC)(T)

  • 2434-53-9

  • 25g

  • 1,180.00CNY

  • Detail
  • Alfa Aesar

  • (B25448)  6-Amino-1-methyluracil, 97%   

  • 2434-53-9

  • 25g

  • 759.0CNY

  • Detail
  • Alfa Aesar

  • (B25448)  6-Amino-1-methyluracil, 97%   

  • 2434-53-9

  • 100g

  • 2439.0CNY

  • Detail
  • Aldrich

  • (346799)  6-Amino-1-methyluracil  97%

  • 2434-53-9

  • 346799-25G

  • 827.19CNY

  • Detail

2434-53-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-amino-1-methylpyrimidine-2,4-dione

1.2 Other means of identification

Product number -
Other names 1-methyl-6-aminouracil

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2434-53-9 SDS

2434-53-9Relevant articles and documents

A uracil nitroso amine based colorimetric sensor for the detection of Cu2+ ions from aqueous environment and its practical applications

Patil, Samadhan R.,Nandre, Jitendra P.,Patil, Prashant A.,Sahoo, Suban K.,Devi, Manisha,Pradeep, Chullikkattil P.,Fabiao, Yu,Chen, Lingxin,Redshaw, Carl,Patil, Umesh D.

, p. 21464 - 21470 (2015)

A simple uracil nitroso amine based colorimetric chemosensor (UNA-1) has been synthesized and screened for its cation recognition ability. Sensor UNA-1 exhibited a high sensitivity and selectivity towards Cu2+ ions in aqueous medium in the presence of a wide range of other competing cations (Ag+, Al3+, Ba2+, Ca2+, Cd2+, Co2+, Cr3+, Cs+, Fe2+, Fe3+, Li+, Mg2+, Mn2+, Na+, Ni2+, Pb2+, Zn2+, Hg2+ and Sr2+). With Cu2+, the sensor UNA-1 gave a distinct color change from colorless to dark yellow by forming a complex of 1:1 stoichiometry. Furthermore, sensor UNA-1 was successfully utilized in the preparation of test strips and supported silica for the detection of Cu2+ ions from aqueous environment.

Molecular and crystal structure of 5,6-diamino-1-methyluracil and 5,6-diamino-1,3-dimethyluracil monohydrate. Semiempirical calculations (AM1 and PM3) on 5,6-diaminouracil derivatives

Hueso-Urena, Francisco,Moreno-Carretero, Miguel N.,Low, John N.,Masterton, Alison G.

, p. 133 - 141 (1997)

The crystal and molecular structures of 5,6-diamino-1-methyluracil and 5,6-diamino-1,3-dimethyluracil monohydrate have been determined from X-ray diffraction. Both compounds are planar and the two amino groups have two different conformations. The substituent at the 5 position seems to be a true primary amino group with a strongly sp3 nitrogen, whereas the one at the 6 position is nearly coplanar with the uracil ring, displaying a predominant sp2 character. Semiempirical calculations were made on 5,6-diaminouracil, 5,6-diamino-2-thiouracil and their endocyclic N-methylated derivatives using the AM1 and PM3 hamiltonians. These indicate that the stability decreases on increasing methylation, the 2-thio compounds always being less stable than the 2-oxo ones.

Linagliptin intermediate compound IV

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Paragraph 0188-0189, (2020/09/09)

The invention belongs to the field of pharmaceutical chemicals, and discloses a linagliptin intermediate IV and a novel route for synthesizing an important linagliptin intermediate from the linagliptin intermediate IV. The linagliptin intermediate IV synthesized in the invention has the advantages of high yield, simple operation, substantial reduction of production cost, suitableness for industrial production; and the synthesis route solves the problems of self-coupling of linagliptin intermediates and generation of large impurities in the prior art.

Linagliptin intermediate compound V

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Paragraph 0185-0186, (2020/09/09)

The invention belongs to the field of pharmaceutical chemicals, and provides a linagliptin intermediate compound V and an important intermediate for synthesizing linagliptin by using the intermediateV. The method solves the problems of self-coupling of linagliptin intermediates and generation of large impurities in the prior art, and the synthesized novel intermediate compound V has the advantages of high yield, simple operation, significantly reduced production cost, and suitableness for industrial production.

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