243640-19-9

Basic information

• Product Name: (R)-(2,3-Dimethoxyphenyl)-4-piperidinemethanol
• Synonyms: (R)-(2,3-Dimethoxyphenyl)-4-piperidinemethanol
• CAS NO: 243640-19-9
• Molecular Formula: C₁₄H₂₁NO₃
• Molecular Weight: 251.32144
• Product Categories: Amines;Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Amines, Aromatics, Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 243640-19-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 404.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.106±0.06 g/cm3(Predicted)
• Solubility: Chloroform, Dichloromethane, Methanol
• PKA: 13.93±0.20(Predicted)
• CAS DataBase Reference: (R)-(2,3-Dimethoxyphenyl)-4-piperidinemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(2,3-Dimethoxyphenyl)-4-piperidinemethanol(243640-19-9)
• EPA Substance Registry System: (R)-(2,3-Dimethoxyphenyl)-4-piperidinemethanol(243640-19-9)

Safety Data

• Hazardous Substances Data: 243640-19-9(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Upstream product

• 139290-70-3 tert-butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate 
• 498-94-2 isonipecotic acid 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 139290-72-5 (2,3-dimethoxyphenyl)(piperidin-4-yl)methanone 
• 139290-71-4 4-(2,3-Dimethoxybenzoyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester 
• 140235-25-2 (+/-)-α-(2,3-dimethoxyphenyl)-4-piperidinemethanol 
• 869749-10-0 (R)-α-(2,3-dimethoxyphenyl)-4-piperidinemethanol, (2R,3R)-(-)-di-(p-anisoyl)tartaric acid salt 
• 869749-09-7 (R)-α-(2,3-dimethoxyphenyl)-4-piperidinemethanol, (2R,3R)-(-)-di-(p-toluoyl)tartaric acid salt 
• 50583-51-2 (2R,3R)-2,3-bis[(4-methoxyphenyl)carbonyloxy]butanedioic acid 

Downstream Products

• 139290-65-6 R-(+)-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol 

Relevant articles and documents

Highly enantioselective hydrogenation and transfer hydrogenation of cycloalkyl and heterocyclic ketones catalysed by an iridium complex of a tridentate phosphine-diamine ligand

Ir complexes of chiral phosphine-diamine ligands catalyse the hydrogenation and transfer hydrogenation of aryl-piperidin-4-yl methanones, and ketones bearing both an aryl group and secondary alkyl substituent with up to 98% e.e., and with substrate to catalyst ratios of up to 4000.

Processes for the preparation of (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol"

The present invention provides various processes for the preparation of (R)-±-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol. These processes may be characterized by the following scheme:

Novel processes for the preparation or (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol

The present invention provides various processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol. These processes may be characterized by the following scheme: