243845-56-9Relevant articles and documents
Photoredox-catalyzed redox-neutral difluoroalkylation to construct perfluoroketones with difluoroenoxysilanes
Lin, Wu-Jie,Liu, Xue-Yuan,Sun, Wen-Hui,Wang, Yu-Zhao,Zou, Jian-Yu
supporting information, p. 8696 - 8700 (2021/10/22)
A mild and facile approach to construct various perfluoroketonesviaphoto-catalyzed difluoroalkylation of difluoroenoxysilanes is developed. The reaction includes a strategy of combination of two fluorine-containing functional groups, which confers the reaction with characteristics like high efficiency, mild conditions, and broad scope. A variety of fluoroalkyl halides including perfluoroalkyl iodides, bromo difluoro esters and amides can be employed as radical precursors. Control experiments indicate that a single-electron transfer pathway may be involved in the reaction.
Visible-light-initiated difluoromethylation of arene diazonium tetrafluoroborates
Wu, Ye-Bin,Lu, Guo-Ping,Zhou, Bao-Jing,Bu, Mei-Jie,Wan, Li,Cai, Chun
supporting information, p. 5965 - 5968 (2016/05/24)
A mild and efficient method for the radical addition of α-aryl-β,β-difluoroenol silyl with arene diazonium tetrafluoroborates at room temperature has been disclosed, which involves an innate radical long chain cycle, so only a small amount (0.05 mol%) of photocatalyst and a short light exposure time are required as radical initiators. A proposed mechanism for the transformation is also illustrated based on the results of control experiments and quantum calculations. A variety of α-aryl-α,α-difluoroketones were formed in moderate to high yields, and can be easily further transformed into various difluoromethylarenes under basic conditions.
A general method of halogenation for synthesis of α-halodifluoromethyl ketones and [18F]-labeled trifluoromethyl ketones
Prakash, G.K. Surya,Hu, Jinbo,Alauddin, Mian M.,Conti, Peter S.,Olah, George A.
, p. 239 - 243 (2007/10/03)
A convenient general method of halogenations suitable for synthesis of α-halodifluoromethyl ketones is reported. Reaction of 2,2-difluoro-1-aryl-1-trimethylsiloxyethenes (difluoro silyl enol ethers) (2a-e) with halogens at low temperature (-30 to -78 °C) produced a high yield of α-halodifluoromethyl ketones (1a-j). This one-step simple method can be highly useful for synthesis of [18F]-labeled α-trifluoromethyl ketones.