2440-60-0

Basic information

• Product Name: o-methylisourea
• Synonyms: o-methylisourea;ORTHO-METHYLISOUREA;Carbamimidic acid methyl ester;Methoxyformamidine;24285-39-0 (Sulfate);29427-58-5 (Monosulfate);52328-05-9 (Sulfate[2:1]);5329-33-9 (Hydrochloride)
• CAS NO: 2440-60-0
• Molecular Formula: C₂H₆N₂O
• Molecular Weight: 74.08184
• Mol File: 2440-60-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 44-45 °C
• Boiling Point: 66.9 °C at 760 mmHg
• Flash Point: 28.4°C
• Appearance: white crystal
• Density: 1.17 g/cm³
• Vapor Pressure: 148mmHg at 25°C
• PKA: pK1:9.72(＋1) (25°C)
• CAS DataBase Reference: o-methylisourea(CAS DataBase Reference)
• NIST Chemistry Reference: o-methylisourea(2440-60-0)
• EPA Substance Registry System: o-methylisourea(2440-60-0)

Safety Data

• Hazardous Substances Data: 2440-60-0(Hazardous Substances Data)

Usage

Description

o-Methylisourea is an organic compound with the chemical formula C2H6N2O. It is a derivative of isourea, where one of the hydrogen atoms is replaced by a methyl group. This modification gives o-methylisourea unique properties that make it useful in various applications.

Uses

Used in Pharmaceutical Industry:
o-Methylisourea is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its ability to form carbamates and other derivatives makes it a versatile building block in the development of new drugs.
Used in Chemical Synthesis:
o-Methylisourea is used as a reagent in the preparation of specific chemical compounds, such as Ph(3-methoxy-1,2,4-thiadiazol-5-yl)carbamate, which is synthesized from o-methylisourea hydrochloride. o-methylisourea has potential applications in various fields, including agriculture and materials science.

InChI:InChI=1/C2H6N2O.ClH/c1-5-2(3)4;/h1H3,(H3,3,4);1H

Upstream product

• 67-56-1 methanol 
• 420-04-2 CYANAMID 
• 5329-33-9 o-methylisourea hydrochloride 
• 57-13-6 urea 
• 77-78-1 dimethyl sulfate 
• 96-45-7 N,N'-ethylenethiourea 
• 137075-21-9 methyl chloride 
• 5586-73-2 3-diphenylpropyl amine 

Downstream Products

• 98071-79-5 N-acetyl-O-methyl-isourea 
• 57988-54-2 N-(4-chloro-phenylcarbamoyl)-O-methyl-isourea 
• 93029-43-7 N-methoxycarboximidoyl-N'-phenyl-thiourea 
• 52386-29-5 6-amino-2-methoxy-3H-4-pyrimidone 
• 147863-96-5 3-guanidino-3-phenyl-propionic acid 
• 57-00-1 Creatinine 
• 860762-74-9 N-(α-bromo-isovaleryl)-O-methyl-isourea 
• 352-83-0 beta-Guanidinobutyric acid 
• 108865-65-2 N-carbamimidoyl-DL-serine 
• 79198-90-6 N-Formamidine-L-leucine 
• 6133-30-8 guanidinosuccinic acid 
• 73477-53-9 N-amidino-L-glutamic acid 
• 18416-85-8 L-lombricine 
• 122631-96-3 D/L-lombricine 

Relevant articles and documents

CARBOCYCLIC NUCLEOSIDE ANALOGUE

The present invention relates to novel hydrolytically stable carbocyclic 5-aza-2-deoxycytidine and carbocyclic 5-aza-cytidine compounds and prodrugs thereof as hypomethylating agents.

Thioimidazoline based compounds reverse glucocorticoid resistance in human acute lymphoblastic leukemia xenografts

Glucocorticoids form a critical component of chemotherapy regimens for pediatric acute lymphoblastic leukemia (ALL) and the initial response to glucocorticoid therapy is a major prognostic factor, where resistance is predictive of poor outcome. A high-throughput screen identified four thioimidazoline-containing compounds that reversed dexamethasone resistance in an ALL xenograft derived from a chemoresistant pediatric ALL. The lead compound (1) was synergistic when used in combination with the glucocorticoids, dexamethasone or prednisolone. Synergy was observed in a range of dexamethasone-resistant xenografts representative of B-cell precursor ALL (BCP-ALL) and T-cell ALL. We describe here the synthesis of twenty compounds and biological evaluation of thirty two molecules that explore the structure-activity relationships (SAR) of this novel class of glucocorticoid sensitizing compounds. SAR analysis has identified that the most effective dexamethasone sensitizers contain a thioimidazoline acetamide substructure with a large hydrophobic moiety on the acetamide. This journal is

Preparation of substituted guanidine derivatives

Substituted guanidine derivatives of the formula I are prepared by a) converting urea into an alkylated isourea of the formula II and b) reacting the alkylated isourea with a primary or secondary amine of the formula III where the substituents R1, R2 and R10 have the meanings explained in the description.