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2440-60-0

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2440-60-0 Usage

Description

o-Methylisourea is an organic compound with the chemical formula C2H6N2O. It is a derivative of isourea, where one of the hydrogen atoms is replaced by a methyl group. This modification gives o-methylisourea unique properties that make it useful in various applications.

Uses

Used in Pharmaceutical Industry:
o-Methylisourea is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its ability to form carbamates and other derivatives makes it a versatile building block in the development of new drugs.
Used in Chemical Synthesis:
o-Methylisourea is used as a reagent in the preparation of specific chemical compounds, such as Ph(3-methoxy-1,2,4-thiadiazol-5-yl)carbamate, which is synthesized from o-methylisourea hydrochloride. o-methylisourea has potential applications in various fields, including agriculture and materials science.

Check Digit Verification of cas no

The CAS Registry Mumber 2440-60-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,4,4 and 0 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 2440-60:
(6*2)+(5*4)+(4*4)+(3*0)+(2*6)+(1*0)=60
60 % 10 = 0
So 2440-60-0 is a valid CAS Registry Number.
InChI:InChI=1/C2H6N2O.ClH/c1-5-2(3)4;/h1H3,(H3,3,4);1H

2440-60-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl carbamimidate

1.2 Other means of identification

Product number -
Other names Methyl imidocarbamate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2440-60-0 SDS

2440-60-0Relevant articles and documents

CARBOCYCLIC NUCLEOSIDE ANALOGUE

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Page/Page column 11; 14, (2020/12/30)

The present invention relates to novel hydrolytically stable carbocyclic 5-aza-2-deoxycytidine and carbocyclic 5-aza-cytidine compounds and prodrugs thereof as hypomethylating agents.

Thioimidazoline based compounds reverse glucocorticoid resistance in human acute lymphoblastic leukemia xenografts

Toscan, Cara E.,Rahimi, Marwa,Bhadbhade, Mohan,Pickford, Russell,McAlpine, Shelli R.,Lock, Richard B.

, p. 6299 - 6312 (2015/06/08)

Glucocorticoids form a critical component of chemotherapy regimens for pediatric acute lymphoblastic leukemia (ALL) and the initial response to glucocorticoid therapy is a major prognostic factor, where resistance is predictive of poor outcome. A high-throughput screen identified four thioimidazoline-containing compounds that reversed dexamethasone resistance in an ALL xenograft derived from a chemoresistant pediatric ALL. The lead compound (1) was synergistic when used in combination with the glucocorticoids, dexamethasone or prednisolone. Synergy was observed in a range of dexamethasone-resistant xenografts representative of B-cell precursor ALL (BCP-ALL) and T-cell ALL. We describe here the synthesis of twenty compounds and biological evaluation of thirty two molecules that explore the structure-activity relationships (SAR) of this novel class of glucocorticoid sensitizing compounds. SAR analysis has identified that the most effective dexamethasone sensitizers contain a thioimidazoline acetamide substructure with a large hydrophobic moiety on the acetamide. This journal is

Preparation of substituted guanidine derivatives

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, (2008/06/13)

Substituted guanidine derivatives of the formula I are prepared by a) converting urea into an alkylated isourea of the formula II and b) reacting the alkylated isourea with a primary or secondary amine of the formula III where the substituents R1, R2 and R10 have the meanings explained in the description.

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