244077-31-4

Basic information

• Product Name: (cis)-2-(3,4-Dimethoxybenzoyl)-1,2,3,6-tetrahydrobenzoic acid
• Synonyms: (cis)-2-(3,4-Dimethoxybenzoyl)-1,2,3,6-tetrahydrobenzoic acid
• CAS NO: 244077-31-4
• Molecular Weight: 290.316
• Mol File: 244077-31-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (cis)-2-(3,4-Dimethoxybenzoyl)-1,2,3,6-tetrahydrobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (cis)-2-(3,4-Dimethoxybenzoyl)-1,2,3,6-tetrahydrobenzoic acid(244077-31-4)
• EPA Substance Registry System: (cis)-2-(3,4-Dimethoxybenzoyl)-1,2,3,6-tetrahydrobenzoic acid(244077-31-4)

Safety Data

• Hazardous Substances Data: 244077-31-4(Hazardous Substances Data)

Upstream product

• 91-16-7 1,2-dimethoxybenzene 
• 85-43-8 1,2,3,6-Tetrahydrophthalic anhydride 
• 935-79-5 cis-1,2,3,6-tetrahydrophthalic anhydride 

Relevant articles and documents

Novel selective phosphodiesterase (PDE4) inhibitors. 4. Resolution, absolute configuration, and PDE4 inhibitory activity of cis-tetra- and cis-hexahydrophthalazinones

Recently, we reported that 4-catechol-substituted cis-(±)-4a,5,6,7,8,8a-hexa- and cis-(±)- 4a,5,8,8a-tetrahydro-2H-phthalazin-1-ones show potent inhibition of phosphodiesterase (PDE4) activity, while the corresponding trans racemic mixtures exhibit only w

Phthalazinones

PCT No. PCT/EP98/00124 Sec. 371 Date Jul. 14, 1999 Sec. 102(e) Date Jul. 14, 1999 PCT Filed Jan. 12, 1998 PCT Pub. No. WO98/31674 PCT Pub. Date Jul. 23, 1998Compounds of formula I wherein R1, R2, R3, R4 and R5 have the means set forth in the description are selective cyclic nucleotide phosphodiesterase (PDE) inhibitors (specifically of type 4), which are effective bronchial therapeutics.