24410-55-7

Basic information

• Product Name: Benzofuran, 7-chloro-
• Synonyms: Benzofuran, 7-chloro-;7-Chlorobenzofuran
• CAS NO: 24410-55-7
• Molecular Formula: C8H5ClO
• Molecular Weight: 152.58
• Mol File: 24410-55-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 209.5°Cat760mmHg
• Flash Point: 80.5°C
• Appearance: /
• Density: 1.289g/cm³
• Vapor Pressure: 0.292mmHg at 25°C
• Refractive Index: 1.615
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: Benzofuran, 7-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzofuran, 7-chloro-(24410-55-7)
• EPA Substance Registry System: Benzofuran, 7-chloro-(24410-55-7)

Safety Data

• Hazardous Substances Data: 24410-55-7(Hazardous Substances Data)

Usage

General Description

Benzofuran, 7-chloro- is a chemical compound with the molecular formula C8H5ClO. It is a chlorinated derivative of benzofuran, which is a heterocyclic organic compound. Benzofuran, 7-chloro- is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It has also been studied for its potential biological activities, including its antibacterial, antifungal, and antitumor properties. The compound is also known to be a potent inhibitor of the enzyme monoamine oxidase, which makes it relevant in the development of treatments for various neurological and psychological disorders. Benzofuran, 7-chloro- is a versatile compound with potential applications in both the pharmaceutical and agricultural industries.

InChI:InChI=1/C8H5ClO/c9-7-3-1-2-6-4-5-10-8(6)7/h1-5H

Upstream product

• 63558-84-9 7-chlorobenzofuran-2-carboxylic acid 
• 121045-28-1 2-chloro-6-<2-hydroxy-1-(isopropylthio)ethyl>phenol 
• 95-57-8 2-monochlorophenol 
• 260273-62-9 ethyl 7-chlorobenzofuran-2-carboxylate 
• 1927-94-2 3-chlorosalicylaldehyde 
• 105474-73-5 1-chloro-2-(2,2-diethoxyethoxy)benzene 

Downstream Products

• 4790-81-2 benzofuran-7-ol 

Relevant articles and documents

Biocatalytic Strategy for Highly Diastereo- and Enantioselective Synthesis of 2,3-Dihydrobenzofuran-Based Tricyclic Scaffolds

2,3-Dihydrobenzofurans are key pharmacophores in many natural and synthetic bioactive molecules. A biocatalytic strategy is reported here for the highly diastereo- and enantioselective construction of stereochemically rich 2,3-dihydrobenzofurans in high enantiopurity (>99.9% de and ee), high yields, and on a preparative scale via benzofuran cyclopropanation with engineered myoglobins. Computational and structure-reactivity studies provide insights into the mechanism of this reaction, enabling the elaboration of a stereochemical model that can rationalize the high stereoselectivity of the biocatalyst. This information was leveraged to implement a highly stereoselective route to a drug molecule and a tricyclic scaffold featuring five stereogenic centers via a single-enzyme transformation. This work expands the biocatalytic toolbox for asymmetric C–C bond transformations and should prove useful for further development of metalloprotein catalysts for abiotic carbene transfer reactions.

New 2-substituted 1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine having highly active and potent central α2-antagonistic activity as potential antidepressants

The synthesis and biological activity of a series of benzofuro[3,2- c]pyridines and a benzothieno[3,2-c]pyridine are described. These compounds exhibit high affinity for the α2-adrenoceptor, with high selectivity versus the α1-receptor. Compound 1 also shows potent in vivo central activity and has been selected for further biological and clinical evaluation.