244136-25-2Relevant articles and documents
Application of modified flavone closure for the preparation of racemic L86-8275
Tabaka, A. Christine,Murthi, Krishna K.,Pal, Kollol,Teleha, Christopher A.
, p. 256 - 259 (2013/09/08)
The laboratory preparation of racemic L86-8275 (1a) and the salt (1b) is described in 7% overall yield. Our method eliminated a number of chromatography steps from the patent procedure and improved the flavone-forming reaction by employing a stepwise mechanism. Solvent-free conditions for the demethylation step are also described.