244141-28-4

Basic information

• Product Name: 6-chloro-9-[3-deoxy-2-O-[(trifluoromethyl)sulfonyl]-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine
• Synonyms: 6-chloro-9-[3-deoxy-2-O-[(trifluoromethyl)sulfonyl]-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine
• CAS NO: 244141-28-4
• Molecular Weight: 645.059
• Mol File: 244141-28-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 6-chloro-9-[3-deoxy-2-O-[(trifluoromethyl)sulfonyl]-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-9-[3-deoxy-2-O-[(trifluoromethyl)sulfonyl]-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine(244141-28-4)
• EPA Substance Registry System: 6-chloro-9-[3-deoxy-2-O-[(trifluoromethyl)sulfonyl]-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine(244141-28-4)

Safety Data

• Hazardous Substances Data: 244141-28-4(Hazardous Substances Data)

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 244140-86-1 6-chloro-9-[3-deoxy-5-O-(triphenylmethyl)-β-D-erythro-pentofuranosyl]-9H-purine 
• 125790-82-1 9-(2,5-di-O-acetyl-3-bromo-3-deoxy-β-D-xylofuranosyl)-1,9-dihydro-6H-purine-6-one 
• 1025373-45-8 trifluoromethanesulfonic acid anhydride 
• 58-63-9 Inosine 
• 76-83-5 trityl chloride 
• 188883-00-3 6-chloro-9-(2,5-di-O-acetyl-3-deoxy-β-D-erythro-pentofuranosyl)-9H-purine 
• 204978-87-0 2',5'-di-O-acetyl-3'-deoxyinosine 
• 6982-08-7 6-chloro-9-(3-deoxy-β-D-erythro-pentofuranosyl)-9H-purine 

Downstream Products

• 244140-87-2 6-chloro-9-[2,3-dideoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl]-9H-purine 
• 234436-55-6 9-[2,3-dideoxy-2-fluoro-5-O-(triphenylmethyl)-β-D-threo-pentofuranosyl]-9H-purine-6-amine 
• 110143-10-7 iodenosine 

Relevant articles and documents

An industrial process for synthesizing lodenosine (FddA)

Two industrial synthetic approaches to Lodenosine (1, FddA, 9-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl) adenine) via a purine riboside or a purine 3′-deoxyriboside are described. Several novel applications of deoxygenation and fluorination methods are compared considering reaction yields, economy, safety and environmental concerns.

Synthesis of 9-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl)adenine (FddA) via a purine 3′-deoxynucleoside

A synthesis of 9-(2,3-dideoxy-2-fluoro-β-D-threo-pentofuranosyl)adenine (1, FddA) via a 6-chloro 9-(3-deoxy-β-D-erythro-pentofuranosyl)-9H-purine (9), which was readily obtained from inosine (5), is described. Fluorination at the C2′-β position of the purine 3′-deoxynucleoside with diethylaminosulfur trifluoride was improved by the introduction of a 6-chloro group and proceeded in moderate yield. Purine 3′-deoxynucleoside derivatives were also subjected to nucleophilic reactions with triethylamine trihydrofluoride and gave the desired fluorinated nucleoside in good yield. The safety and yield of the fluorination process were greatly improved by the use of triethylamine trihydrofluoride. The influence of the sugar ring conformation and 6-chloro group on the rate of the nucleophilic reaction against elimination are also discussed.