24423-98-1Relevant articles and documents
Synthesis and Properties of Halohydroxyacetones and Halomethylglyoxals
Chari, Ravi V.J.,Kozarich, John W.
, p. 2355 - 2358 (1982)
A short, high-yield synthetic scheme for the preparation of halohydroxyacetones (4) and halomethylglyoxals (6) from the corresponding 3-halopyruvic acids is described.The key intermediate to both classes is the dimethyl ketal (3) of the halohydroxyacetone (4).The ketal alkohol (3) may be hydrolyzed to 4 or oxidized to the corresponding aldehyde (5) which, in turn, may be hydrolyzed to the halomethylglyoxal (6).Halohydroxyacetones (4) exist in solution as an equilibrium mixture of the free ketone and hydrate.Halomethylglyoxals (6) occur nearly exclusively as the dihydrates species.Some other properties of these compounds are described.
The selective solid-phase oxidation of alcohols and other organic substrates by 3,5-dimethylpyrazolium fluorochromate
Chaudhuri,Dehury,Hussain,Duarah,Gogoi
, p. 331 - 336 (2007/10/03)
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PROCESS FOR PRODUCING OPTICALLY ACTIVE HALOPROPANEDIOL DERIVATIVE
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Page 17, (2008/06/13)
The present invention provides a method capable of simply producing optically active halopropanediol derivatives useful as pharmaceutical intermediates from inexpensive raw materials.Monohalohydroxyacetone derivatives can be produced by reacting propargyl alcohol derivatives available at low cost and a hypohalogenous acid to convert the propargyl alcohol derivatives to di- or tri-halohydroxyacetone derivatives, and then hydrogenating the derivatives in the present of a transition metal catalyst. Also, optically active halopropanediol derivatives can be produced by stereoselectively reducing the halohydroxyacetone derivatives with an enzyme source having the ability to stereoselectively reduce the carbonyl groups of the halohydroxyacetone derivatives.