244236-52-0

Basic information

• Product Name: ethyl 2-(tert-butoxycarbonylamino)-4-methylthiazole-5-carboxylate
• Synonyms: ethyl 2-(tert-butoxycarbonylamino)-4-methylthiazole-5-carboxylate
• CAS NO: 244236-52-0
• Molecular Formula: C₁₂H₁₈N₂O₄S
• Molecular Weight: 286.34732
• Mol File: 244236-52-0.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 2-(tert-butoxycarbonylamino)-4-methylthiazole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(tert-butoxycarbonylamino)-4-methylthiazole-5-carboxylate(244236-52-0)
• EPA Substance Registry System: ethyl 2-(tert-butoxycarbonylamino)-4-methylthiazole-5-carboxylate(244236-52-0)

Safety Data

• Hazardous Substances Data: 244236-52-0(Hazardous Substances Data)

Upstream product

• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 
• 141-97-9 ethyl acetoacetate 
• 7210-76-6 ethyl-2-amino-4-methylthiazole-5-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 302963-94-6 2-[[(tert-butyloxy)carbonyl]amino]-4-methyl-1,3-thiazole-5-carboxylic acid 
• 302958-04-9 [5-[[(2,4-dimethylphenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester 
• 302957-83-1 [5-[[(2,4,6-Trimethylphenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid, 1,1-dimethylethyl ester 
• 302957-93-3 [5-[[phenylamino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid, 1,1-dimethylethyl ester 
• 302958-05-0 [4-methyl-5-[[(2-methylphenyl)amino]carbonyl]-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester 
• 302958-00-5 [5-[[(2-methoxy-6-methylphenyl)amino]-carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester 
• 302958-06-1 [5-[[(2-chloro-6-methylphenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester 
• 302958-40-3 [5-[[(2,6-dimethylphenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester 
• 302958-03-8 [4-methyl-5-[[[2-methyl-6-(1-methylethyl)phenyl]-amino]carbonyl]-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester 
• 302958-02-7 [5-[[(4-bromo-2,6-dimethylphenyl)amino]-carbonyl]-4-methyl-2-thiazolyl]carbamic acid 1,1-dimethylethyl ester 
• 302957-95-5 [5-[[(2,4-dichlorophenyl)amino]carbonyl]-4-methyl-2-thiazolyl]carbamic acid, 1.1-dimethylethyl ester 
• 1215121-73-5 tert-butyl (5-(hydroxymethyl)-4-methylthiazol-2-yl)carbamate 
• 482584-84-9 tert-butyl (5-formyl-4-methylthiazol-2-yl)carbamate 
• 1184958-37-9 (S)-ethyl 2-(3-(4-fluorobenzyl)-4-methyl-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylate 

Relevant articles and documents

MYC INHIBITORS AND USES THEREOF

Disclosed herein, inter alia, are compounds for inhibiting N-MYC or Aurora A Kinase and uses thereof.

NOVEL COMPOUNDS

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.

HETEROCYCLIC INHIBITORS OF STEAROYL-COA DESATURASE

The present invention provides heterocyclic derivatives of formula (I) that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising