244246-71-7

Basic information

• Product Name: 3-Bromo-2-trifluoromethylaniline
• Synonyms: 3-Bromo-2-trifluoromethylaniline
• CAS NO: 244246-71-7
• Molecular Formula: C7H5BrF3N
• Molecular Weight: 240.0205096
• Mol File: 244246-71-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 3-Bromo-2-trifluoromethylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-2-trifluoromethylaniline(244246-71-7)
• EPA Substance Registry System: 3-Bromo-2-trifluoromethylaniline(244246-71-7)

Safety Data

• Hazardous Substances Data: 244246-71-7(Hazardous Substances Data)

Usage

General Description

3-Bromo-2-trifluoromethylaniline is an organic compound with the chemical formula C7H5BrF3N. It is a bromo-trifluoromethyl substituted aniline derivative and is well known for its applications in organic synthesis and pharmaceutical industry. 3-Bromo-2-trifluoromethylaniline is a useful intermediate in the synthesis of various pharmaceuticals, agrochemicals, and organic compounds. Its unique structure and properties make it a valuable building block for the development of new materials and compounds. Furthermore, it is also used in the production of dyes and pigments. However, its use should be handled with caution as it is a potentially hazardous chemical.

Upstream product

• 887144-94-7 Togni's reagent II 
• 591-19-5 m-Bromoaniline 

Relevant articles and documents

Nickel-Catalyzed Direct C-H Trifluoromethylation of Free Anilines with Togni's Reagent

An efficient nickel-catalyzed C-H trifluoromethylation for the synthesis of trifluoromethylated free anilines using Togni's reagent has been developed. This approach exhibits a good functional group tolerance, good regioselectivity, and chemoselectivity under mild conditions. The newly developed economical one-step method is a better alternative to synthesize trifluoromethylated free anilines.

A for the preparation of ortho-trifluoromethyl-aniline or its derivatives (by machine translation)

The invention discloses a method for preparing o-trifluoromethyl phenylamine and derivatives thereof. According to the method, phenylamine or a phenylamine derivative serving as raw material reacts with a trivalent iodine reagent compound 2 in a solution under the protection of argon or nitrogen and illumination condition in the presence of tri(2-phenylpyridine)-iridium [Ir(ppy)3] serving as a catalyst to produce o-trifluorophenylamine or derivatives thereof 3, wherein the trivalent iodine reagent compound 2 has a structure shown in the specification. The method is mild in reaction conditions, the amino does not need to be protected, and trifluoromethyl substituted phenylamine or phenylamine derivatives can be directly obtained.