24460-06-8

Basic information

• Product Name: 2'-amino-6'-(diethylamino)spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one
• Synonyms: 2'-amino-6'-(diethylamino)spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one;2'-Amino-6'-diethylaminospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one;Einecs 246-270-5;Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 2'-amino-6'-(diethylamino)-
• CAS NO: 24460-06-8
• Molecular Formula: C₂₄H₂₂N₂O₃
• Molecular Weight: 386.44308
• EINECS: 246-270-5
• Mol File: 24460-06-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2'-amino-6'-(diethylamino)spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-amino-6'-(diethylamino)spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one(24460-06-8)
• EPA Substance Registry System: 2'-amino-6'-(diethylamino)spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one(24460-06-8)

Safety Data

• Hazardous Substances Data: 24460-06-8(Hazardous Substances Data)

Usage

Fluorescence

Emits bright red light under ultraviolet or blue light exposure.

Structure

Spirocyclic structure belonging to the xanthene class of dyes.

Applications

Used in microscopy and flow cytometry for fluorescent labeling and tracing.
Employed in inks, textiles, and as a colorant in cosmetic products.

Controversy

Potential toxicity and adverse health effects.
Banned or restricted in some regions for use in food and consumer products.

Upstream product

• 26567-31-7 C₂₆H₂₄N₂O₄ 
• 103-90-2 4-acetaminophenol 
• 5809-23-4 2'-Carboxy-4-diethylamino-2-hydroxybenzophenon 
• 123-30-8 4-amino-phenol 
• 85-44-9 phthalic anhydride 
• 91-68-9 3-diethylaminophenol 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 24460-39-7 C₂₈H₃₀N₂O₃ 
• 34372-72-0 3-(Diethylamino)-7-(dibenzylamino)-xanthen>-3-one 

Relevant articles and documents

A fluoran-based fluorescent probe via a strategy of blocking the intramolecular photoinduced electron transfer (PET) process

A novel fluoran-based fluorescent probe 2 has been designed and synthesized by using a strategy of blocking the intramolecular photoinduced electron transfer (PET) process. The probe keeps a ring-closed spirolactone structure in aqueous buffer solution. However, the oxidation of the probe by ClO? perturbs a new equilibrium of the structural interconversion between the nonfluorescent spirolactone and the fluorescent ring-opened zwitterion, which generates a highly selective fluorescent probe for ClO?. Meanwhile, the probe is cell membrane permeable and can be utilized as fluorescent probe for imaging ClO? in living cells.

Absorption, fluorescence, and acid-base equilibria of rhodamines in micellar media of sodium dodecyl sulfate

Rhodamine dyes are widely used as molecular probes in different fields of science. The aim of this paper was to ascertain to what extent the structural peculiarities of the compounds influence their absorption, emission, and acid-base properties under unified conditions. The acid-base dissociation (HR+???R?+?H+) of a series of rhodamine dyes was studied in sodium n-dodecylsulfate micellar solutions. In this media, the form R exists as a zwitterion R±. The indices of apparent ionization constants of fifteen rhodamine cations HR+ with different substituents in the xanthene moiety vary within the range of pKaapp?=?5.04 to 5.53. The distinct dependence of emission of rhodamines bound to micelles on pH of bulk water opens the possibility of using them as fluorescent interfacial acid–base indicators.