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24468-13-1

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24468-13-1 Usage

Description

2-Ethylhexyl chloroformate is a colorless to light yellow colored liquid that is denser than water. It has the potential to cause irritation upon contact with skin, eyes, and mucous membranes. Additionally, it is considered toxic if ingested, inhaled, or absorbed through the skin.

Uses

Used in Pharmaceutical Industry:
2-Ethylhexyl chloroformate is used as a reagent for the synthesis of various pharmaceutical compounds due to its ability to react with different functional groups and facilitate the formation of desired products.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-Ethylhexyl chloroformate is utilized as a protecting group for alcohols, which is crucial for the selective protection of functional groups during multi-step reactions.
Used in Research and Development:
2-Ethylhexyl chloroformate is employed as a research tool in the development of new chemical processes and methodologies, particularly in the synthesis of complex organic molecules and the study of reaction mechanisms.
Used in Industrial Applications:
This chloroformate is also used in various industrial applications, such as the production of specialty chemicals, agrochemicals, and other fine chemicals, where its reactivity and selectivity are advantageous.

Air & Water Reactions

Produces corrosive toxic fumes containing HCl on contact with moist air. Decomposes in water.

Reactivity Profile

2-Ethylhexyl chloroformate is water reactive. Incompatible with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

Flammability and Explosibility

Nonflammable

Check Digit Verification of cas no

The CAS Registry Mumber 24468-13-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,4,6 and 8 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 24468-13:
(7*2)+(6*4)+(5*4)+(4*6)+(3*8)+(2*1)+(1*3)=111
111 % 10 = 1
So 24468-13-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H17ClO2/c1-3-5-6-8(4-2)7-12-9(10)11/h8H,3-7H2,1-2H3

24468-13-1 Well-known Company Product Price

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  • Aldrich

  • (249769)  2-Ethylhexylchloroformate  ≥98%

  • 24468-13-1

  • 249769-100G

  • 838.89CNY

  • Detail

24468-13-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-ethylhexyl carbonochloridate

1.2 Other means of identification

Product number -
Other names Carbonochloridic acid,2-ethylhexyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Intermediates
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:24468-13-1 SDS

24468-13-1Synthetic route

phosgene
75-44-5

phosgene

2-Ethylhexyl alcohol
104-76-7

2-Ethylhexyl alcohol

2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

Conditions
ConditionsYield
With toluene
2-Ethylhexyl alcohol
104-76-7

2-Ethylhexyl alcohol

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃; for 2h;
2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

4,6-O-benzylidene-1-O-methyl-α-D-glucopyranoside
3162-96-7

4,6-O-benzylidene-1-O-methyl-α-D-glucopyranoside

C32H50O10

C32H50O10

Conditions
ConditionsYield
With N,N,N,N,-tetramethylethylenediamine In dichloromethane at 0℃; for 1h;99%
2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

2-ethylhexanoyl 2-ethylhexyl carbonate
334513-51-8

2-ethylhexanoyl 2-ethylhexyl carbonate

Conditions
ConditionsYield
98%
2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

ethanolamine
141-43-5

ethanolamine

2-N-(2-ethylhexyloxycarbonyl)amino-1-ethanol
176516-34-0

2-N-(2-ethylhexyloxycarbonyl)amino-1-ethanol

Conditions
ConditionsYield
With sodium hydrogencarbonate98%
3-Amino-1,2-propanediol
616-30-8, 13552-31-3

3-Amino-1,2-propanediol

2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

3-N-(2-ethylhexyloxycarbonyl)amino-1,2-propanediol
176516-38-4

3-N-(2-ethylhexyloxycarbonyl)amino-1,2-propanediol

Conditions
ConditionsYield
With sodium bicarbonate In tetrahydrofuran; water; acetone97%
N-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'-1H-indazol-4-ylurea
808756-71-0

N-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'-1H-indazol-4-ylurea

2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

2-ethylhexyl 4-(3-((R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl)ureido)-1H-indazole-1-carboxylate

2-ethylhexyl 4-(3-((R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl)ureido)-1H-indazole-1-carboxylate

Conditions
ConditionsYield
Stage #1: N-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'-1H-indazol-4-ylurea With potassium tert-butylate In tetrahydrofuran; N,N-dimethyl-formamide for 0.0833333h;
Stage #2: 2-Ethylhexyl chloroformate In tetrahydrofuran; N,N-dimethyl-formamide for 0.333333h;
97%
1-Amino-1-deoxy-D-glucitol
488-43-7

1-Amino-1-deoxy-D-glucitol

2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

N-2-ethylhexyloxycarbonyl-D-glucamine
176516-32-8

N-2-ethylhexyloxycarbonyl-D-glucamine

Conditions
ConditionsYield
With sodium hydrogencarbonate95%
tert.-butylhydroperoxide
75-91-2

tert.-butylhydroperoxide

2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

OO-tert-butyl O-(2-ethylhexyl) monoperoxycarbonate
34443-12-4

OO-tert-butyl O-(2-ethylhexyl) monoperoxycarbonate

Conditions
ConditionsYield
In water at 55℃;95%
With pyridine; sodium hydroxide at 35℃; for 2.2h; Temperature; Reagent/catalyst;
4-HYDROXYPIPERIDINE
5382-16-1

4-HYDROXYPIPERIDINE

2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

2-ethylhexyl 4-hydroxy-1-piperidinecarboxylate
945842-96-6

2-ethylhexyl 4-hydroxy-1-piperidinecarboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane for 1h;94%
2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate
147403-65-4

methyl 2-ethoxy-1-((2′-(N′-hydroxycarbamimidoyl)-biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate

C34H40N4O6

C34H40N4O6

Conditions
ConditionsYield
With pyridine In N,N-dimethyl-formamide at 0℃; for 0.5h; Cooling with ice;92.2%
With pyridine In N,N-dimethyl-formamide at 0℃; for 0.5h;
With pyridine In N,N-dimethyl-formamide at 0℃; for 0.5h; Cooling with water-ice;
2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

di-(2-ethylhexyl)-peroxydicarbonate
16111-62-9

di-(2-ethylhexyl)-peroxydicarbonate

Conditions
ConditionsYield
With dihydrogen peroxide In water at 30 - 35℃;92%
With dihydrogen peroxide; sodium carbonate In water at 0 - 10℃; for 0.0618333h; Temperature; Reagent/catalyst; Flow reactor;90.4%
With sodium hydroxide; water; dihydrogen peroxide
2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

2-ethylhexyl carbamate
4248-21-9

2-ethylhexyl carbamate

Conditions
ConditionsYield
With ammonia In tetrahydrofuran; water at 0 - 20℃; Inert atmosphere;89%
2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

4,4'-(1,2-ethanediyl)bis(1-hydroxymethyl-2,6-piperazinedione)
98631-86-8

4,4'-(1,2-ethanediyl)bis(1-hydroxymethyl-2,6-piperazinedione)

1,2-bis[4-(2-ethylhexyloxycarbonyloxymethyl)-3,5-dioxopiperazin-1-yl]ethane
98632-27-0

1,2-bis[4-(2-ethylhexyloxycarbonyloxymethyl)-3,5-dioxopiperazin-1-yl]ethane

Conditions
ConditionsYield
With pyridine Ambient temperature;86%
2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

3-(chloromethyl)heptane
123-04-6

3-(chloromethyl)heptane

Conditions
ConditionsYield
With N,N-dimethyl-formamide In chloroform at 72℃;86%
pyrographite
N-(2-hydroxypropyl-3-hexadecyloxy)ethanolamine

N-(2-hydroxypropyl-3-hexadecyloxy)ethanolamine

2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

N-(2-ethylhexyloxycarbonyl)-N-(2-hydroxy-3-hexadecyloxypropyl) ethanolamine

N-(2-ethylhexyloxycarbonyl)-N-(2-hydroxy-3-hexadecyloxypropyl) ethanolamine

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran; water84%
2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

2,9-bis(p-methylaminomethylphenyl)-1,10-phenanthroline

2,9-bis(p-methylaminomethylphenyl)-1,10-phenanthroline

{4-[9-(4-{[(2-ethyl-hexyloxycarbonyl)-methyl-amino]-methyl}-phenyl)-[1,10]phenanthrolin-2-yl]-benzyl}-methyl-carbamic acid 2-ethyl-hexyl ester

{4-[9-(4-{[(2-ethyl-hexyloxycarbonyl)-methyl-amino]-methyl}-phenyl)-[1,10]phenanthrolin-2-yl]-benzyl}-methyl-carbamic acid 2-ethyl-hexyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃;82%
2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

eflornithine hydrochloride

eflornithine hydrochloride

sodium 2-amino-2-difluoromethyl-5-({[(2-ethylhexyl)oxy]carbonyl}amino)pentanoate

sodium 2-amino-2-difluoromethyl-5-({[(2-ethylhexyl)oxy]carbonyl}amino)pentanoate

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 120h; pH=11;80%
(E)-1-(4-tolylthio)-3,3,3-trifluoroprop-1-ene
940881-02-7

(E)-1-(4-tolylthio)-3,3,3-trifluoroprop-1-ene

2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

2-ethylhex-1-yl (E)-4,4,4-trifluoro-2-(p-tolylthio)but-2-enoate

2-ethylhex-1-yl (E)-4,4,4-trifluoro-2-(p-tolylthio)but-2-enoate

Conditions
ConditionsYield
Stage #1: (E)-1-(4-tolylthio)-3,3,3-trifluoroprop-1-ene With n-butyllithium; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran; hexane at -78℃;
Stage #2: 2-Ethylhexyl chloroformate In tetrahydrofuran; hexane at -78℃; for 0.25h; Further stages.;
76%
Stage #1: (E)-1-(4-tolylthio)-3,3,3-trifluoroprop-1-ene With N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran at -78 - 20℃; Inert atmosphere;
Stage #2: With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.166667h; Inert atmosphere;
Stage #3: 2-Ethylhexyl chloroformate In tetrahydrofuran; hexane at -78℃; for 0.25h; Inert atmosphere;
76%
3-(5-chloro-2-methoxy-benzenesulfonylamino)-N-[4-(N-hydroxycarbamimidoyl)-phenyl]-benzamide
916167-81-2

3-(5-chloro-2-methoxy-benzenesulfonylamino)-N-[4-(N-hydroxycarbamimidoyl)-phenyl]-benzamide

2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

3-(5-Chloro-2-methoxy-benzenesulfonylamino)-N-[4-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-phenyl]-benzamide

3-(5-Chloro-2-methoxy-benzenesulfonylamino)-N-[4-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-phenyl]-benzamide

Conditions
ConditionsYield
Stage #1: 3-(5-chloro-2-methoxy-benzenesulfonylamino)-N-[4-(N-hydroxycarbamimidoyl)-phenyl]-benzamide; 2-Ethylhexyl chloroformate With pyridine In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: In xylene at 100 - 145℃; for 2h;
75%
2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

tert-butyl 4-{5-[(Z)-amino(hydroxyimino)methyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}piperidine-1-carboxylate
1037839-03-4, 1037834-91-5

tert-butyl 4-{5-[(Z)-amino(hydroxyimino)methyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}piperidine-1-carboxylate

tert-butyl 4-[2-oxo-5-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-benzimidazol-1-yl]piperidine-1-carboxylate
1037834-90-4

tert-butyl 4-[2-oxo-5-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-benzimidazol-1-yl]piperidine-1-carboxylate

Conditions
ConditionsYield
With pyridine In o-xylene at 0℃; for 4.25h; Heating / reflux;74%
2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

phenylhydrazine
100-63-0

phenylhydrazine

2-ethylhexyl 2-phenylhydrazinecarboxylate
40887-07-8

2-ethylhexyl 2-phenylhydrazinecarboxylate

Conditions
ConditionsYield
With pyridine at 5 - 20℃; for 2h;73%
With pyridine
4-(5-chloro-2-methoxy-benzenesulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid [4-(N-hydroxycarbamimidoyl)-phenyl]-amide

4-(5-chloro-2-methoxy-benzenesulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid [4-(N-hydroxycarbamimidoyl)-phenyl]-amide

2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

4-(5-Chloro-2-methoxy-benzenesulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid [4-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-phenyl]-amide

4-(5-Chloro-2-methoxy-benzenesulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid [4-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-phenyl]-amide

Conditions
ConditionsYield
Stage #1: 4-(5-chloro-2-methoxy-benzenesulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid [4-(N-hydroxycarbamimidoyl)-phenyl]-amide; 2-Ethylhexyl chloroformate With pyridine In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: In xylene for 2h; Heating / reflux;
73%
2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

N-(3-hydroxyphenyl)-diphenylamine
107396-23-6

N-(3-hydroxyphenyl)-diphenylamine

4-(1-pyrenyl)butyric acid 1-bromo-2-ethylhexane

4-(1-pyrenyl)butyric acid 1-bromo-2-ethylhexane

Conditions
ConditionsYield
With triethylamine In chloroform at 20℃; for 1h;72%
2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

hydroquinone
123-31-9

hydroquinone

1,4-bis-(1-(2-ethylhexyl))-phenylene carbonate

1,4-bis-(1-(2-ethylhexyl))-phenylene carbonate

Conditions
ConditionsYield
With pyridine; dmap In ethyl acetate for 24h; Ambient temperature;71%
2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

C36H46N2O4
1218938-62-5

C36H46N2O4

Ethyl E-8-[2-(4-tert-butylbenzyloxy)phenyl]-6-{2-[4-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)phenyl]ethyl}oct-7-enoate
934753-54-5

Ethyl E-8-[2-(4-tert-butylbenzyloxy)phenyl]-6-{2-[4-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)phenyl]ethyl}oct-7-enoate

Conditions
ConditionsYield
Stage #1: 2-Ethylhexyl chloroformate; C36H46N2O4 With pyridine In N,N-dimethyl-formamide at 0℃; for 0.5h;
Stage #2: In xylene for 2h; Reflux;
70%
2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

arabinosyl cytosine
147-94-4

arabinosyl cytosine

[1-((2R,3S,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-carbamic acid 2-ethyl-hexyl ester

[1-((2R,3S,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-carbamic acid 2-ethyl-hexyl ester

Conditions
ConditionsYield
With sodium hydrogencarbonate In N,N-dimethyl acetamide Ambient temperature;65%
3-{[2'-(acetylamino)-4'-methyl-4,5'-bi-1,3-thiazol-2-yl]amino}-N-hydroxybenzenecarboximidic acid

3-{[2'-(acetylamino)-4'-methyl-4,5'-bi-1,3-thiazol-2-yl]amino}-N-hydroxybenzenecarboximidic acid

2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

N-(2-{[3-(5-hydroxy-l-2,4-oxadiazol-3-yl) phenyl]amino}-4'-methyl-4,5'-bi-1,3-thiazol-2'-yl)acetamide

N-(2-{[3-(5-hydroxy-l-2,4-oxadiazol-3-yl) phenyl]amino}-4'-methyl-4,5'-bi-1,3-thiazol-2'-yl)acetamide

Conditions
ConditionsYield
With pyridine In DMF (N,N-dimethyl-formamide) at 0℃; for 0.5h;64.7%
2-Ethylhexyl chloroformate
24468-13-1

2-Ethylhexyl chloroformate

hydroquinone
123-31-9

hydroquinone

<1-(2-ethylhexyl)>-(4-oxy-phenylene) carbonate

<1-(2-ethylhexyl)>-(4-oxy-phenylene) carbonate

Conditions
ConditionsYield
With pyridine; dmap In ethyl acetate for 24h; Ambient temperature;62%

24468-13-1Relevant articles and documents

Design and Comparative Evaluation of the Anticonvulsant Profile, Carbonic-Anhydrate Inhibition and Teratogenicity of Novel Carbamate Derivatives of Branched Aliphatic Carboxylic Acids with 4-Aminobenzensulfonamide

Bibi, David,Mawasi, Hafiz,Nocentini, Alessio,Supuran, Claudiu T.,Wlodarczyk, Bogdan,Finnell, Richard H.,Bialer, Meir

, p. 1972 - 1982 (2017)

Epilepsy is one of the most common neurological diseases, with between 34 and 76 per 100,000 people developing epilepsy annually. Epilepsy therapy for the past 100+ years is based on the use of antiepileptic drugs (AEDs). Despite the availability of more than twenty old and new AEDs, approximately 30% of patients with epilepsy are not seizure-free with the existing medications. In addition, the clinical use of the existing AEDs is restricted by their side-effects, including the teratogenicity associated with valproic acid that restricts its use in women of child-bearing age. Thus, there is an unmet clinical need to develop new, effective AEDs. In the present study, a novel class of carbamates incorporating phenethyl or branched aliphatic chains with 6–9 carbons in their side-chain, and 4-benzenesulfonamide-carbamate moieties were synthesized and evaluated for their anticonvulsant activity, teratogenicity and carbonic anhydrase (CA) inhibition. Three of the ten newly synthesized carbamates showed anticonvulsant activity in the maximal-electroshock (MES) and 6?Hz tests in rodents. In mice, 3-methyl-2-propylpentyl(4-sulfamoylphenyl)carbamate(1), 3-methyl-pentan-2-yl-(4-sulfamoylphenyl)carbamate (9) and 3-methylpentyl, (4-sulfamoylphenyl)carbamate (10) had ED50 values of 136, 31 and 14?mg/kg (MES) and 74, 53, and 80?mg/kg (6?Hz), respectively. Compound (10) had rat-MES-ED50 = 13?mg/kg and ED50 of 59?mg/kg at the mouse-corneal-kindling test. These potent carbamates (1,9,10) induced neural tube defects only at doses markedly exceeding their anticonvuslnat-ED50 values. None of these compounds were potent inhibitors of CA IV, but inhibited CA isoforms I, II and VII. The anticonvulsant properties of these compounds and particularly compound 10 make them potential candidates for further evaluation and development as new AEDs.

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