24512-63-8 Usage
Description
Geniposide, an iridoid glycoside, is a biologically active ingredient derived from the fruit of Gardenia jasminoides Ellis. It is a primary reference substance with assigned absolute purity, which takes into account chromatographic purity, water, residual solvents, and inorganic impurities. Geniposide is known for its various therapeutic properties and is widely utilized in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
Geniposide is used as a key ingredient in multi-component injections for the treatment of cerebrovascular diseases. It is valued for its ability to improve blood circulation and provide neuroprotective effects, making it a crucial component in managing and treating such conditions.
Used in Traditional Medicine:
Geniposide is also utilized in traditional medicine, particularly in Chinese medicine, where it is known for its detoxifying and anti-inflammatory properties. It is often used to treat conditions such as jaundice and inflammation.
Used in Drug Development:
Due to its various biological activities, Geniposide is a promising candidate for drug development. Researchers are exploring its potential in developing new medications for a range of health conditions, including neurological disorders and inflammatory diseases.
Pharmacological effects
Geniposide, also known as Gardenia glycosides, geniposide. It is a brown to white crystalline powder, with little flavor and no bitter taste, a cycloolefin ether glycoside compound extracted from the dry and ripe fruit of Rubiaceae Gardenia. Geniposide has a significant role in promoting bile secretion, and can reduce blood bilirubin, as well as promote rapid excretion of bilirubin in the blood. It has an inhibitory effect on Streptococcus hemolyticus and skin fungi. It also has antipyretic, analgesic, sedative, antihypertensive and hemostatic effects. Geniposide has the function of purging pathogenic fire and eliminating restlessness, clearing heat and eliminating damp, decreasing swellinging to relieving pain. The Indications of Geniposide are heat disease, dysphoria, coma delirium, jaundice, heat stranguria, heat in blood, swelling and pain of eye, pathopyretic ulcer, and sprain.
Biochem/physiol Actions
Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activity. Geniposide has been shown to regulate Nrf2 translocation and upregulate downstream antioxidant protein HO-1 expression through the PI3K/Akt signaling pathway, which may account for its neuroprotective and antioxidative activity. Glucagon-like peptide 1 (GLP-1) receptor may also play a critical role in geniposide induced HO-1 expression.
Check Digit Verification of cas no
The CAS Registry Mumber 24512-63-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,5,1 and 2 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 24512-63:
(7*2)+(6*4)+(5*5)+(4*1)+(3*2)+(2*6)+(1*3)=88
88 % 10 = 8
So 24512-63-8 is a valid CAS Registry Number.
24512-63-8Relevant articles and documents
Guarnaccia et al.
, p. 5125 (1972)
Asymmetric total synthesis of the iridoid β-glucoside (+)-geniposide via phosphine organocatalysis
Jones, Regan A.,Krische, Michael J.
supporting information; experimental part, p. 1849 - 1851 (2009/09/06)
Phosphine-catalyzed [3 + 2] cycloaddition of ethyl-2, 3-butadienoate with enone (S)-3b occurs with high levels of regio- and stereocontrol to deliver the c/s-fused cyclopenta[c]pyran 4 characteristic of the iridoid family of natural products. Cycloadduct 4 was converted to the iridoid glycoside (+)-geniposide in 10 steps.
The constituents of Eucommia ulmoides OLIV. IV. Isolation of a new sesquilignan glycoside and iridoids
Deyama,Ikawa,Kitagawa,Nishibe
, p. 4933 - 4938 (2007/10/02)
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