245121-96-4

Basic information

• Product Name: 1,1-Dimethoxy-2-hydroxy-4-phenylbutyl-1-(diphenylphosphine oxide)
• Synonyms: 1,1-Dimethoxy-2-hydroxy-4-phenylbutyl-1-(diphenylphosphine oxide)
• CAS NO: 245121-96-4
• Molecular Weight: 410.45
• Mol File: 245121-96-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,1-Dimethoxy-2-hydroxy-4-phenylbutyl-1-(diphenylphosphine oxide)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-Dimethoxy-2-hydroxy-4-phenylbutyl-1-(diphenylphosphine oxide)(245121-96-4)
• EPA Substance Registry System: 1,1-Dimethoxy-2-hydroxy-4-phenylbutyl-1-(diphenylphosphine oxide)(245121-96-4)

Safety Data

• Hazardous Substances Data: 245121-96-4(Hazardous Substances Data)

Upstream product

• 1079-66-9 chloro-diphenylphosphine 
• 104-53-0 3-phenyl-propionaldehyde 
• 86658-86-8 (dimethoxymethyl)diphenylphosphane oxide 

Downstream Products

• 7226-82-6 (RS)-2-hydroxy-4-phenylbutanoic acid methyl ester 
• 68844-69-9 (2R)-2-Hydroxy-4-phenylbutyric acid methyl ester 
• 129990-77-8 (2S)-2-Hydroxy-4-phenylbutyric acid methyl ester 

Relevant articles and documents

Lithiated dimethoxymethyl diphenyl phosphine oxide, a versatile formiate carbanion equivalent

Aldehydes are homologated to the corresponding α-hydroxy methyl esters using lithiated dimethoxymethyl diphenyl phosphine oxide. The primary addition product of this Horner-Wittig process collapses to the corresponding α-hydroxy ester under proton-catalyzed conditions.