24534-37-0Relevant articles and documents
Synthesis and biological evaluation of 2-arylbenzofuran derivatives as potential anti-Alzheimer’s disease agents
Yun, Yinling,Miao, Yuhang,Sun, Xiaoya,Sun, Jie,Wang, Xiaojing
, p. 1346 - 1356 (2021/06/26)
Alzheimer's disease (AD) is a type of progressive dementia caused by degeneration of the nervous system. A single target drug usually does not work well. Therefore, multi-target drugs are designed and developed so that one drug can specifically bind to mu
Deconstructive Reorganization: De Novo Synthesis of Hydroxylated Benzofuran
Cao, Tongxiang,Jiang, Huanfeng,Zhang, Ling,Zhu, Shifa
supporting information, p. 4670 - 4677 (2020/02/20)
An unprecedented deconstructive reorganization strategy for the de novo synthesis of hydroxylated benzofurans from kojic acid- or maltol-derived alkynes is reported. In this reaction, both the benzene and furan rings were simultaneously constructed, whereas the pyrone moiety of the kojic acid or maltol was deconstructed and then reorganized into the benzene ring as a six-carbon component. Through this strategy, at least one free hydroxyl group was introduced into the benzene ring in a substitution-pattern tunable fashion without protection–deprotection and redox adjustment. With this method, a large number of hydroxylated benzofuran derivatives with different substitution-patterns have been prepared efficiently. This methodology has also been shown as the key step in a collective total synthesis of hydroxylated benzofuran-containing natural products (11 examples).
HYDROPHILIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES
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, (2018/09/21)
The present invention relates to novel compounds, particularly to compounds comprising a photoactive unit, said novel compounds being particularly suitable for compositions and ophthalmic devices as well as to compositions and ophthalmic devices comprising such compounds.
