24542-74-3 Usage
Description
1-(2,6-Dichlorophenyl)indole-2,3-dione is an organic compound derived from the indole-2,3-dione structure, featuring a 2,6-dichlorophenyl group attached to the first position. This molecule is characterized by its unique chemical properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
1-(2,6-Dichlorophenyl)indole-2,3-dione is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its presence in the synthesis process contributes to the development of potent and balanced norepinephrine and serotonin reuptake inhibitors, which are essential for treating conditions such as depression and anxiety.
Used in Chemical Synthesis:
In the field of chemical synthesis, 1-(2,6-Dichlorophenyl)indole-2,3-dione serves as a valuable reactant for the production of various compounds, including 3-(phenoxy-phenyl-methyl)-pyrrolidines. These compounds have demonstrated potential as effective reuptake inhibitors, further expanding the applications of this versatile molecule.
Used in Quality Control and Impurity Analysis:
1-(2,6-Dichlorophenyl)indole-2,3-dione is also recognized as an impurity in the synthesis of Diclofenac, a widely used nonsteroidal anti-inflammatory drug (NSAID). Its identification and analysis are crucial for ensuring the quality and safety of Diclofenac products, as well as for optimizing the synthesis process to minimize the formation of impurities.
Check Digit Verification of cas no
The CAS Registry Mumber 24542-74-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,5,4 and 2 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 24542-74:
(7*2)+(6*4)+(5*5)+(4*4)+(3*2)+(2*7)+(1*4)=103
103 % 10 = 3
So 24542-74-3 is a valid CAS Registry Number.
24542-74-3Relevant articles and documents
The effect of humidity on the stability of diclofenac sodium in inclusion complex with β-cyclodextrin in the solid state
Hladon, Teresa,Cwiertnia
, p. 943 - 944 (2007/10/03)
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Synthesis and quantitative structure-activity relationships of diclofenac analogues
Moser,Sallmann,Wiesenberg
, p. 2358 - 2368 (2007/10/02)
The synthesis of a series of 2-anilinophenylacetic acid, close analogues of diclofenac, is described. These compounds were tested in two models used for evaluating the activity of nonsteroidal antiinflammatory drugs (NSAID's), inhibition of cyclooxygenase enzyme activity in vitro, and adjuvant-induced arthritis (AdA) in rats. Statistically significant correlations were found between the inhibitory activities of the compounds in these two models, indicating that cyclooxygenase inhibition seems to be the underlying mechanism for the antiinflammatory activity of these compounds. Quantitative structure-activity relationship (QSAR) analysis revealed that the crucial parameters for activity in both models were the lipophilicity and the angle of twist between the two phenyl rings. Optimal activities were associated with halogen or alkyl substituents in both ortho positions of the anilino ring. Compounds with OH groups in addition to two ortho substituents or compounds with only one or no ortho substituents were less active.
