245434-89-3

Basic information

• Product Name: 1-(chloromethyl)-3-(methoxymethoxy)benzene
• Synonyms: 1-(chloromethyl)-3-(methoxymethoxy)benzene
• CAS NO: 245434-89-3
• Molecular Weight: 186.638
• Mol File: 245434-89-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(chloromethyl)-3-(methoxymethoxy)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(chloromethyl)-3-(methoxymethoxy)benzene(245434-89-3)
• EPA Substance Registry System: 1-(chloromethyl)-3-(methoxymethoxy)benzene(245434-89-3)

Safety Data

• Hazardous Substances Data: 245434-89-3(Hazardous Substances Data)

Usage

Description

1-(chloromethyl)-3-(methoxymethoxy)benzene is a chemical compound with the molecular formula C9H11ClO2. It is a benzene derivative that contains a chloromethyl group and a methoxymethoxy group attached to the benzene ring. 1-(chloromethyl)-3-(methoxymethoxy)benzene is known for its unique reactivity due to the presence of these functional groups, which makes it a versatile building block in organic synthesis and a valuable intermediate in the production of pharmaceuticals and agrochemicals.

Uses

Used in Organic Synthesis:
1-(chloromethyl)-3-(methoxymethoxy)benzene is used as a building block for the synthesis of various organic compounds. Its unique reactivity, stemming from the chloromethyl and methoxymethoxy groups, allows for the creation of a wide range of chemical products.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 1-(chloromethyl)-3-(methoxymethoxy)benzene is used as an intermediate in the production of various drugs. Its functional groups can be further modified or reacted with other molecules to create active pharmaceutical ingredients.
Used in Agrochemical Production:
Similarly, in the agrochemical industry, 1-(chloromethyl)-3-(methoxymethoxy)benzene serves as an intermediate for the synthesis of different agrochemicals, such as pesticides and herbicides. Its versatility in organic synthesis makes it a valuable component in the development of these products.

Upstream product

• 107-30-2 chloromethyl methyl ether 
• 99-06-9 3-Carboxyphenol 
• 100-83-4 meta-hydroxybenzaldehyde 
• 13709-05-2 3-methoxymethoxybenzaldehyde 
• 81245-42-3 methyl 3-{[(methyloxy)methyl]oxy}benzoate 

Downstream Products

• 1337929-70-0 WZB-131 
• 1403778-17-5 1-((4-(tert-butyl)phenoxy)methyl)-3-(methoxymethoxy)benzene 
• 1403778-18-6 3-((4-(tert-butyl)phenoxy)methyl)phenol 

Relevant articles and documents

Isosteres of ester derived glucose uptake inhibitors

Glucose transporters (GLUTs) facilitate glucose uptake and are overexpressed in most cancer cells. Inhibition of glucose transport has been shown to be an effective method to slow the growth of cancer cells both in vitro and in vivo. We have previously reported on the anticancer activity of an ester derived glucose uptake inhibitor. Due to the hydrolytic instability of the ester linkage we have prepared a series of isosteres of the ester moiety. Of all of the isosteres prepared, the amine linkage showed the most promise. Several additional analogues of the amine-linked compounds were also prepared to improve the overall activity.

Photochemical generation of oxa-dibenzocyclooctyne (ODIBO) for metal-free click ligations

Oxa-dibenzocyclooctynes (ODIBO, 2a-c) are prepared by photochemical decarbonylation of corresponding cyclopropenones (photo-ODIBO, 1a-c). While photo-ODIBO does not react with azides, ODIBO is one of the most reactive cyclooctynes exhibiting rates of cycloaddition over 45 M-1 s -1 in aqueous solutions. ODIBO is stable under ambient conditions and has low reactivity towards thiols. Photo-ODIBO survives heating up to 160 °C and does not react with thiols.

Bicyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof

Novel pharmaceutically/cosmetically-active bicyclic aromatic compounds have the structural formula (I): in which Ar1 is a radical having one of the structural formulae (a)-(c): Ar2 is a radical having one of the following formulae (d)-(h): and X is a radical having one of the following formulae (i)-(l): and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.