245672-37-1

Basic information

• Product Name: (+/-)-benzyl [1-[(2-oxo-4-oxazolidinyl)methyl]-2,5-cyclohexadien-1-yl]methyl malonate
• Synonyms: (+/-)-benzyl [1-[(2-oxo-4-oxazolidinyl)methyl]-2,5-cyclohexadien-1-yl]methyl malonate
• CAS NO: 245672-37-1
• Molecular Weight: 385.417
• Mol File: 245672-37-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (+/-)-benzyl [1-[(2-oxo-4-oxazolidinyl)methyl]-2,5-cyclohexadien-1-yl]methyl malonate(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-benzyl [1-[(2-oxo-4-oxazolidinyl)methyl]-2,5-cyclohexadien-1-yl]methyl malonate(245672-37-1)
• EPA Substance Registry System: (+/-)-benzyl [1-[(2-oxo-4-oxazolidinyl)methyl]-2,5-cyclohexadien-1-yl]methyl malonate(245672-37-1)

Safety Data

• Hazardous Substances Data: 245672-37-1(Hazardous Substances Data)

Upstream product

• 40204-26-0 malonic acid monobenzyl ester 
• 245672-36-0 (+/-)-4-[[1-(hydroxymethyl)-2,5-cyclohexadienyl]methyl]-2-oxazolidinone 

Downstream Products

• 245672-39-3 (+/-)-benzyl [1-4-oxo-[(2-oxo-4-oxazolidinyl)methyl]-2,5-cyclohexadien-1-yl]methyl malonate 

Relevant articles and documents

Intramolecular conjugate addition reactions of amines and carbamates to 2,5-cyclohexadien-1-ones: Stereoselective synthesis of perhydroindoles

Intramolecular conjugate addition reactions of 4,4-disubstituted-2,5- cyclohexadien-1-ones are described within the context of possible approaches to manzamine A. Amine 4 provided tricycle 6, with improper relative stereochemistry for use in an approach to manzamine A. Carbamates 25 and 38 gave perhydroindoles 26 and 28 b under conditions of thermodynamic control, respectively, with the proper relative stereochemistry required for manzamine A. Carbamate 25 gave diastereomeric perhydroindole 27 under conditions of thermodynamic control.