245681-61-2

Basic information

• Product Name: Benzoic acid (1R,2S)-2,3-dihydroxy-1-methyl-propyl ester
• Synonyms: Benzoic acid (1R,2S)-2,3-dihydroxy-1-methyl-propyl ester
• CAS NO: 245681-61-2
• Molecular Weight: 210.23
• Mol File: 245681-61-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzoic acid (1R,2S)-2,3-dihydroxy-1-methyl-propyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid (1R,2S)-2,3-dihydroxy-1-methyl-propyl ester(245681-61-2)
• EPA Substance Registry System: Benzoic acid (1R,2S)-2,3-dihydroxy-1-methyl-propyl ester(245681-61-2)

Safety Data

• Hazardous Substances Data: 245681-61-2(Hazardous Substances Data)

Downstream Products

• 245681-55-4 (10S,11R)-11-benzoyloxy-10-(1,1-dimethylethyl)dimethylsiloxy-2,4,6,8-dodecatetraenal 
• 245681-54-3 (6S,7R)-7-benzoyloxy-6-(1,1-dimethylethyl)dimethylsiloxy-2,4-octadienal 
• 198955-26-9 (2R,3R)-3-benzoyloxy-2-(1,1-dimethylethyl)dimethylsiloxy-butanal 
• 198955-25-8 (2S,3R)-3-O-benzoyl-2-O-(1,1-dimethylethyl)dimethylsilyl-butane-1,2,3-triol 

Relevant articles and documents

Total synthesis of Filipin III

Filipin III (1), a polyene macrolide antibiotic, has been synthesized for the first time. The polyol chain was assembled using a stereoselective carbon-carbon bond forming strategy previously developed in our lab: a cyanohydrin acetonide alkylation and reductive decyanation sequence. The polyene segment was prepared from L-ascorbic acid. These two components were coupled using Yamaguchi's esterification, and cyclized with an intramolecular Horner-Emmons reaction to form a trisubstituted alkene. Stereoselective reduction followed by deprotection gave filipin III. This highly convergent approach to filipin III represents the first total synthesis of a methylpentaene macrolide antibiotic.