245759-61-9 Usage
General Description
The chemical compound (1R)-1-[4-(benzyloxy)-3-nitrophenyl]-2-{[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino}ethanol is a complex molecule with a long and detailed name. It contains a nitro group, a benzyl ether, an amino group, and a hydroxyl group, among other functional groups. The compound has a chiral center, indicating that it can exist as two enantiomers. The presence of the benzyl, nitro, and methoxy groups suggests that the compound may have biological or pharmaceutical activities, as these functional groups are commonly found in drugs and natural products with medicinal properties. Overall, this compound is likely to have a diverse range of chemical and pharmacological properties due to its complex structure.
Check Digit Verification of cas no
The CAS Registry Mumber 245759-61-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,4,5,7,5 and 9 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 245759-61:
(8*2)+(7*4)+(6*5)+(5*7)+(4*5)+(3*9)+(2*6)+(1*1)=169
169 % 10 = 9
So 245759-61-9 is a valid CAS Registry Number.
245759-61-9Relevant articles and documents
An efficient enantioselective synthesis of (R,R)-formoterol, a potent bronchodilator, using lipases
Campos, Francisco,Bosch, M. Pilar,Guerrero, Angel
, p. 2705 - 2717 (2007/10/03)
The potent β2-adrenergic receptor agonist formoterol (R,R)-1 has been obtained in enantiomerically pure form by a convenient chemoenzymatic approach by coupling of epoxide (R)-6 with the unprotected primary amine (R)-9. Both chiral precursors have been prepared by enantiodifferentiation processes involving Pseudomonas cepacia (lipase PS) and Candida antarctica lipase (CALB), respectively. For the resolution of amine 9, we have found that utilization of triethylamine as non-reactive base enhances the reaction rate and the enantioselectivity of the process. The key coupling reaction of (R)-6 and (R)-9 has been conducted through derivatization of the amine with the labile trimethylsilyl group, which liberates the amino group of the resulting amino alcohol (R,R)-11 upon column chromatography purification. In this way, the overall approach is shorter than others previously described. Copyright (C) 2000 Elsevier Science Ltd.
