24603-63-2

Basic information

• Product Name: 5-Chloro-1,2-benzisoxazol-3(2H)-one
• Synonyms: 5-Chloro-1,2-benzisoxazol-3(2H)-one;5-Chloro-3-hydroxybenzisoxazole;5-Chlorobenzo[d]isoxazol-3-ol, 97%;5-chloro-2,3-dihydro-1,2-benzoxazol-3-one;5-chlorobenzo[d]isoxazol-3(2H)-one
• CAS NO: 24603-63-2
• Molecular Formula: C₇H₄ClNO₂
• Molecular Weight: 169.567
• Mol File: 24603-63-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 216-220 ºC
• Boiling Point: 336.7 °C at 760 mmHg
• Flash Point: 157.4 °C
• Appearance: /
• Density: 1.486
• PKA: 13.19±0.20(Predicted)
• CAS DataBase Reference: 5-Chloro-1,2-benzisoxazol-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-1,2-benzisoxazol-3(2H)-one(24603-63-2)
• EPA Substance Registry System: 5-Chloro-1,2-benzisoxazol-3(2H)-one(24603-63-2)

Safety Data

• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 24603-63-2(Hazardous Substances Data)

Usage

General Description

5-Chloro-1,2-benzisoxazol-3(2H)-one is a chemical compound with the molecular formula C7H4ClNO2. This substance falls under the category of chlorobenzoic acids and derivatives. Its molecular weight is 169.566 g/mol. It is commonly used in the field of scientific research, particularly in the synthesis of other organic compounds. This chemical is not naturally occurring and must be produced in a lab setting through specific chemical reactions.

Upstream product

• 37551-43-2 N-(5-chlorosalicyl) hydroxamic acid 
• 16263-53-9 3,5-dichloro-1,2-benzoisoxazole 
• 37551-43-2 5-chloro-2,N-dihydroxy-benzamide 
• 21725-69-9 3-hydroxybenzisoxazole 
• 4068-78-4 methyl 5-chloro-2-hydroxybenzoate 

Downstream Products

• 16263-53-9 3,5-dichloro-1,2-benzoisoxazole 
• 16263-61-9 5-chloro-3-phenoxy-benzo[d]isoxazole 
• 24603-52-9 5-chloro-2-cyclohexanecarbonyl-benzo[d]isoxazol-3-one 
• 24603-60-9 5-chloro-3-(toluene-4-sulfonyloxy)-benzo[d]isoxazole 
• 24603-59-6 5-chloro-2-(4-nitro-benzoyl)-benzo[d]isoxazol-3-one 
• 24603-55-2 4-methoxy-benzoic acid 5-chloro-benzo[d]isoxazol-3-yl ester 
• 24603-54-1 3-benzoyloxy-5-chloro-benzo[d]isoxazole 

Relevant articles and documents

Benzo[d]isoxazol-3-ol DAAO inhibitors

Methods for increasing D-Serine concentration and reducing concentration of the toxic products of D-Serine oxidation, for enhancing learning, memory and/or cognition, or for treating schizophrenia, Alzheimer's disease, ataxia, or neuropathic pain, or preventing loss in neuronal function characteristic of neurodegenerative diseases involve administering to a subject in need of treatment a therapeutic amount of a compound of formula I, or a pharmaceutically acceptable salt or solvate thereof: wherein Z1 is N or CR3; Z2 is N or CR4; Z3is O or S; A is hydrogen, alkyl or M+; M is aluminum, calcium, lithium, magnesium, potassium, sodium, zinc or a mixture thereof; R1, R2, R3 and R4 are independently selected from hydrogen, alkyl, hydroxy alkoxy, aryl, acyl, halo, cyano, haloalkyl, NHCOOR5 and SO2NH2; R5 is aryl, arylalkyl, heteroaryl or heteroarylalkyl; at least one of R1, R2, R3 and R4 is other than hydrogen; and at least one of Z1 and Z2 is other than N.

Isoxazole derivatives

An isoxazole compound having the following formula: wherein R1 represents hydrogen, halogen, alkyl, alkoxy, hydroxyl, alkylthio, amino, alkanoyl, alkanoylamino, alkanoyloxy, alkoxycarbonyl, carboxy, (alkylthio)thiocarbonyl, carbamoyl, nitro or cyano; R2 represents an amino; m is 1; n is 1 to 6; ring A represents a phenyl ring or a naphthyl ring; and X represents oxygen or sulfur. The isoxazole compound has an excellent monoamine oxidase inhibitory activity, and is useful for treating Parkinson's disease, depression and Alzheimer's disease.

3-Substituierte 5-Amino-1,2-benzisoxazole

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