2462-31-9

Basic information

• Product Name: Benzyl glycinate hydrochloride
• Synonyms: BENZYL GLYCINATE HYDROCHLORIDE;L-GLYCINE BENZYL ESTER HYDROCHLORIDE;H-GLY-OBZL HCL;Glycine phenylmethyl ester hydrochloride;GLYCINE-OBZL HCL;GLYCINE BENZYL ESTER HCL;GLYCINE BENZYL ESTER HYDROCHLORIDE;Gly-OBzl·HCl
• CAS NO: 2462-31-9
• Molecular Formula: C₉H₁₁NO₂*ClH
• Molecular Weight: 201.65
• Product Categories: Amino Acid Derivatives;Glycine [Gly, G];Amino hydrochloride;Amino Acids & Derivatives;Inhibitors
• Mol File: 2462-31-9.mol
• Article Data: 10

Chemical Properties

• Melting Point: 138-140°C
• Boiling Point: 245.5 °C at 760 mmHg
• Flash Point: 110.3 °C
• Appearance: White to off-white powder
• Density: 1.132 g/cm³
• Vapor Pressure: 0.0146mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: −20°C
• Solubility: DMSO, Methanol, Water
• CAS DataBase Reference: Benzyl glycinate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Benzyl glycinate hydrochloride(2462-31-9)
• EPA Substance Registry System: Benzyl glycinate hydrochloride(2462-31-9)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 2462-31-9(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Potent crosslinking inhibitors.

InChI:InChI=1/C9H11NO2/c1-12-9(11)7-10-8-5-3-2-4-6-8/h2-6,10H,7H2,1H3

Upstream product

• 56-40-6 glycine 
• 100-51-6 benzyl alcohol 
• 54244-69-8 tert-butoxycarbonylamino-acetic acid benzyl ester 
• 4530-20-5 BOC-glycine 
• 100-39-0 benzyl bromide 

Downstream Products

• 102556-92-3 N-benzyloxycarbonylglycyl-DL-serylglycine benzyl ester 
• 20902-64-1 carbobenzoxy-L-asparaginylglycine benzyl ester 
• 73488-66-1 N-trityl-glycine benzyl ester 
• 25557-93-1 dibenzyl 2,2'-(carbonylbis(azanediyl))diacetate 
• 102659-71-2 Benzyloxycarbonyl-β-cyan-α-L-alanyl-glycin-benzylester 
• 37579-77-4 Boc-Tyr(Bzl)-Gly-OBzl 
• 137022-74-3 Boc-D-Leu-Gly-NHOBzl 
• 96609-67-5 [2-(2-Nitro-benzoylamino)-benzoylamino]-acetic acid benzyl ester 
• 24628-91-9 Boc-Ser(Bzl)-Gly-OBzl 
• 120297-51-0 Z2>Arg-Gly-OBzl 
• 135468-90-5 Benzyl-3,4-<<(O-benzylglycino)carbonyl>(cyan)methylen>-3,4-didesoxy-α-D-arabinopyranosid 
• 65895-26-3 Nps-Leu-Gly-OBzl 
• 79118-26-6 Boc-Val-Aib-Gly-OBzl 
• 147529-24-6 [2-(2-tert-Butylsulfanyl-1-phenyl-ethoxycarbonylamino)-acetylamino]-acetic acid benzyl ester 

Relevant articles and documents

Design, Synthesis and Biological Evaluation of Bengamide Analogues as ClpP Activators

To combat multidrug-resistant Gram-positive bacteria, new antimicrobials particularly those with novel mechanism of action are badly needed. Different with conventional antibiotics which are typical inhibitors, small-molecule activators of bacterial ClpP represent a new class of antibiotics. No ClpP activator has been developed for clinical trial. Herein, we conducted a screening on our library of bengamide-like ring-opened analogues and found that L472-2 possesses a low minimum inhibitory concentration (MIC) against S.aureus and shows no activity for ClpP activation in vitro, but it displayed reduced antibacterial activity against S. aureus with clpP deletion. In order to obtain bengamide analogues that activate ClpP in vitro as well as possess antibacterial activity, we perform further structural modifications starting from L472-2. Compound 37 remains the antimicrobial activity and activation of ClpP protein in vitro, which could be viewed as a new chemical scaffold for ClpP activators and worthy of further investigation.

N-transfer reagent and method for preparing the same and its application

Provided are a novel N-transfer reagent and a method for preparing the same and its application. The N-transfer reagent is represented by the following Formula (I): The various novel N-transfer reagents of the present invention can be quickly prepared by employing different nitrobenzene precursors. The N-transfer reagents can directly convert a variety of amino compounds into diazo compounds under mild conditions. Particularly, the N-transfer reagents can facilitate the synthesis of the diazo compounds. The application of synthesizing diazo compounds of the present invention can greatly decrease the difficulty in operation, increase the safety during experiments, reduce the cost of production and the environmental pollution, and enhance the industrial value of diazo compounds.

COMPOSITIONS AND METHODS OF USING THE COMPOSITIONS FOR PLAQUE SOFTENING

Disclosed herein is a compound for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of calcified plaque. Methods of treatment comprising applying the disclosed composition are also disclosed. Plaque-softening compounds are also disclosed.