2465-91-0

Basic information

• Product Name: Tetra(Cyanoethoxymethyl) Methane
• Synonyms: Tetra(Cyanoethoxymethyl) Methane
• CAS NO: 2465-91-0
• Molecular Formula: C₁₇H₂₄N₄O₄
• Molecular Weight: 348.39686
• Mol File: 2465-91-0.mol
• Article Data: 25

Chemical Properties

• Melting Point: 43.4-43.9 °C
• Boiling Point: 610.6°C at 760 mmHg
• Flash Point: 232°C
• Appearance: /
• Density: 1.13g/cm³
• Vapor Pressure: 7.54E-15mmHg at 25°C
• Refractive Index: 1.479
• CAS DataBase Reference: Tetra(Cyanoethoxymethyl) Methane(CAS DataBase Reference)
• NIST Chemistry Reference: Tetra(Cyanoethoxymethyl) Methane(2465-91-0)
• EPA Substance Registry System: Tetra(Cyanoethoxymethyl) Methane(2465-91-0)

Safety Data

• Hazardous Substances Data: 2465-91-0(Hazardous Substances Data)

Usage

Description

Tetra(Cyanoethoxymethyl) Methane is an alkyl chain-based molecule that serves as a versatile and functional linker in the synthesis of Proteolysis Targeting Chimeras (PROTACs). It is characterized by its cyanoethoxymethyl groups, which can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion, providing a range of possibilities for chemical modifications and applications in the field of protein degradation.

Uses

Used in Pharmaceutical Industry:
Tetra(Cyanoethoxymethyl) Methane is used as a linker for the development of PROTACs, which are a promising class of therapeutics for the targeted degradation of specific proteins. The ability to hydrolyze, reduce, or eject the nitrile groups allows for the fine-tuning of the linker's properties, enhancing the specificity and efficacy of the resulting PROTACs in modulating protein-protein interactions and addressing various disease states.
Used in Chemical Synthesis:
In the field of chemical synthesis, Tetra(Cyanoethoxymethyl) Methane can be employed as a versatile building block for the creation of complex molecules and compounds. The reactivity of the nitrile groups enables a range of chemical reactions, such as hydrolysis, reduction, and cyanide ion ejection, which can be harnessed to synthesize a variety of molecules with diverse applications in different industries.
Used in Research and Development:
Tetra(Cyanoethoxymethyl) Methane serves as a valuable tool in research and development, particularly in the study of protein degradation and the development of novel therapeutic strategies. Its unique properties and reactivity make it an attractive candidate for the design and synthesis of new molecules with potential applications in various fields, including drug discovery, materials science, and biotechnology.

InChI:InChI=1/C17H24N4O4/c18-5-1-9-22-13-17(14-23-10-2-6-19,15-24-11-3-7-20)16-25-12-4-8-21/h1-4,9-16H2

Upstream product

• 115-77-5 Pentaerythritol 
• 107-13-1 acrylonitrile 

Downstream Products

• 1049690-42-7 C₄₂H₃₉Cl₁₅N₂O₁₃ 
• 183370-86-7 tetra(2-pentachloro-phenoxycarbonyl-ethoxymethyl)methane 
• 132491-88-4 tetrakis[(carboxyethoxy)methyl]methane tetrachloride 
• 35638-19-8 tetrakis(4-carboxy-2-oxabutyl)methane 

Relevant articles and documents

Highly conductive electrolytes derived from nitrile solvents

A series of new low molecular weight nitrile solvents has been designed and synthesized for secondary lithium battery electrolytes. Lithium bis(trifluoromethylsulonyl) imide (LiTFSI) salt concentration and temperature dependent ionic conductivity, electrochemical stability and thermal properties have been studied. The best ionic conductivity, 12.9 × 10-3 S/cm at 25°C, was observed with 1.60M LiTFSI in 2,2-bis(hydroxymethyl)-1,3-propanedi-2-ethylcyano solvent. Both electrolytes and neat solvents displayed freezing point below -80°C.

Preparation and application of three-branch RGD modified brain glioma targeting lipid material

The invention discloses a three-branch RGD-modified glioma targeting lipid material which is used for targeted delivery of brain glioma treatment drugs. One end of the novel lipid material is connected with cholesterol extending through polyethylene glycol, and the other end of the novel lipid material is connected with RGD peptide with brain glioma targeting function, and the novel lipid material can be used for integrin receptor α which is highly expressed on the surface of brain capillary endothelial cells and brain glioma cells. v β3 The affinity between the brain glioma is achieved through the affinity between the brain glioma, and the effective concentration of the therapeutic drug to the brain tumor is improved. The novel lipid lipid material can be used for liposome. The prepared paclitaxel liposome has obvious brain targeting property and tumor targeting property, and has wide application prospects.

NUCLEOPHILE-TRIGGERED DEGRADBLE MATERIALS AND METHODS OF MAKING AND USING THE SAME

Disclosed herein are degradable materials comprising the reaction product of an oxanorbomadiene crosslinker or derivative thereof and a multivalent nucleophile-terminated compound, wherein the reaction product is a degradable elastic solid capable of entraining cargo. Also disclosed herein are degradable materials comprising a polymeric and hyperbranched crosslinked material made with oxanorbomadiene linkage that can be activated for cleavage at a predetermined rate by addition of a nucleophile. Also disclosed herein are methods of making and using the same.

Antibodies that inhibit metalloproteins

An antibody is disclosed which comprises an antigen recognition region which comprises six CDR amino acid sequences selected from the group consisting of SEQ ID NOs: 4-15. Uses thereof are also disclosed.