246538-17-0

Basic information

• Product Name: 3'-C-carbobenzyloxyamino-3'-deoxythymidine
• Synonyms: 3'-C-carbobenzyloxyamino-3'-deoxythymidine
• CAS NO: 246538-17-0
• Molecular Weight: 375.381
• Mol File: 246538-17-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3'-C-carbobenzyloxyamino-3'-deoxythymidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-C-carbobenzyloxyamino-3'-deoxythymidine(246538-17-0)
• EPA Substance Registry System: 3'-C-carbobenzyloxyamino-3'-deoxythymidine(246538-17-0)

Safety Data

• Hazardous Substances Data: 246538-17-0(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 52450-18-7 3'-amino-3'-deoxythymidine 
• 30516-87-1 3'-azido-2',3'-deoxythymidine 

Downstream Products

• 246538-21-6 Methanesulfonic acid (R)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-[(2S,3S,5R)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-propyl ester 
• 246538-22-7 Toluene-4-sulfonic acid (R)-3-[(2S,3S,5R)-3-benzyloxycarbonylamino-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-propyl ester 
• 246538-20-5 [(2S,3S,5R)-2-{(R)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-hydroxy-propyl}-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-carbamic acid 9H-fluoren-9-ylmethyl ester 
• 246538-39-6 1-[(2R,3aS,7S,7aS)-7-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-4-(2,2,2-trifluoro-acetyl)-octahydro-furo[3,2-b]pyridin-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 276679-06-2 C₅₂H₆₅N₆O₁₃PSi 
• 315665-53-3 C₄₆H₅₁N₆O₁₃P 
• 276679-07-3 C₅₀H₆₁N₅O₁₂Si 
• 315665-56-6 7-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-hexahydro-furo[3,2-b]pyridine-4-carboxylic acid 3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester 
• 246538-35-2 3-[(2S,3S,5R)-3-Benzyloxycarbonylamino-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-propionic acid ethyl ester 
• 246538-32-9 3'-C-carbobenzyloxyamino-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5'(S)-C-hydroxyethylthymidine 
• 246538-19-2 3'-C-carbobenzyloxyamino-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5'(R)-C-hydroxyethylthymidine 
• 246538-23-8 3'-C-amino-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3-N,5'(R)-C-ethylenethymidine 
• 246538-18-1 3'-C-carbobenzyloxyamino-3'-deoxy-5'(R,S)-C-ethoxycarbonylmethylthymidine 
• 246538-34-1 [(2S,3S,5R)-2-Formyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-carbamic acid benzyl ester 

Relevant articles and documents

Conformationally locked nucleosides. Synthesis of oligodeoxynucleotides containing 3'-amino-3'-deoxy-3'-N,5'(R)-C-ethylenethymidine

3'-Amino-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-N,5'(R)-C-ethylenethymidine (6) was synthesized starting from 3'-azido-3'-deoxythymidine. Condensation of 6 with 5'-O-(H-phosphonyl)thymidine and 5'-O-(p-nitrophenoxycarbonyl)thymidine derivatives gave dinucleotide and dinucleoside derivatives, respectively, which were incorporated into oligodeoxynucleotides (ODNs). Tm data of the modified ODNs are also presented.