246872-13-9

Basic information

• Product Name: Methanone, bis[3,5-bis(trifluoromethyl)phenyl]-, O-[(4-methylphenyl)sulfonyl]oxime
• CAS NO: 246872-13-9
• Molecular Formula: C24H13F12NO3S
• Molecular Weight: 623.419
• Mol File: 246872-13-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Methanone, bis[3,5-bis(trifluoromethyl)phenyl]-, O-[(4-methylphenyl)sulfonyl]oxime(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, bis[3,5-bis(trifluoromethyl)phenyl]-, O-[(4-methylphenyl)sulfonyl]oxime(246872-13-9)
• EPA Substance Registry System: Methanone, bis[3,5-bis(trifluoromethyl)phenyl]-, O-[(4-methylphenyl)sulfonyl]oxime(246872-13-9)

Safety Data

• Hazardous Substances Data: 246872-13-9(Hazardous Substances Data)

Upstream product

• 175136-66-0 3,3',5,5'-tetrakis(trifluoromethyl)benzophenone(bis[3,5-bis(trifluoromethyl)phenyl])methanone 
• 98-59-9 p-toluenesulfonyl chloride 
• 246872-11-7 3,3',5,5'-tetrakis(trifluoromethyl)benzophenone oxime 

Downstream Products

• 246872-21-9 N-{bis[3,5-bis(trifluoromethyl)phenyl]methylidene}(4-methoxyaniline) 
• 246872-19-5 N-{bis[3,5-bis(trifluoromethyl)phenyl]methylidene}(2-methoxyaniline) 
• 246872-18-4 N-{bis[3,5-bis(trifluoromethyl)phenyl]methylidene}aniline 
• 246872-20-8 N-{bis[3,5-bis(trifluoromethyl)phenyl]methylidene}(3-methoxyaniline) 
• 246872-23-1 N-{bis[3,5-bis(trifluoromethyl)phenyl]methylidene}(2,6-dimethylaniline) 
• 246872-22-0 N-{bis[3,5-bis(trifluoromethyl)phenyl]methylidene}(4-fluoroaniline) 

Relevant articles and documents

Preparation of primary amines by the alkylation of O-sulfonyloximes of benzophenone derivatives with Grignard reagents

Primary amines are prepared by the electrophilic amination of Grignard reagents with benzophenone O-sulfonyloxime derivatives. 4,4'- Bis(trifluoromethyl)benzophenone O-sulfonyloximes react with alkyl Grignard reagents in the presence of a catalytic amount of CuCN in tetrahydrofuran- hexamethylphosphoric triamide to give N-alkylimines, which are readily hydrolyzed to primary amines. 3,3',5,5'-Tetrakis(trifluoromethyl)benzophenone O-p-tolylsulfonyloxime is arylated to the corresponding N-arylimines with aryl Grignard reagents in ether-toluene, and hydrolysis of the resulting imines gives aniline derivatives.