247016-69-9 Usage
Description
6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitriledihydrochloride is a complex organic compound with a unique molecular structure. It is characterized by its multiple amine and cyano groups, as well as its pyridine and carbonitrile moieties. 6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitriledihydrochloride has potential applications in various fields due to its structural properties and functional groups.
Uses
Used in Pharmaceutical Industry:
6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitriledihydrochloride is used as a DPP-IV inhibitor for the treatment of type 2 diabetes. Its potent antihyperglycemic activity and excellent oral bioavailability make it a promising candidate for the development of new diabetes medications.
Used in Drug Delivery Systems:
In the field of drug delivery, 6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitriledihydrochloride can be utilized as a carrier molecule for the targeted delivery of therapeutic agents. Its structural properties allow for the attachment of various drug molecules, enabling controlled and efficient release at the desired site of action.
Used in Chemical Research:
6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitriledihydrochloride can also be employed in chemical research as a building block for the synthesis of novel compounds with potential applications in various industries, such as agriculture, materials science, and environmental science.
Check Digit Verification of cas no
The CAS Registry Mumber 247016-69-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,4,7,0,1 and 6 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 247016-69:
(8*2)+(7*4)+(6*7)+(5*0)+(4*1)+(3*6)+(2*6)+(1*9)=129
129 % 10 = 9
So 247016-69-9 is a valid CAS Registry Number.
247016-69-9Relevant articles and documents
Solid and solution phase syntheses of the 2-cyanopyrrolidide DPP-IV inhibitor NVP-DPP728
Willand, Nicolas,Joossens, Jurgen,Gesquière, Jean-Claude,Tartar, André L,Evans, D.Michael,Roe, Michael B
, p. 5741 - 5746 (2002)
DPP-IV inhibitors have been suggested as potential new treatments for type-II diabetes and 2-cyanopyrrolidides have been reported as potent DPP-IV inhibitors. Alternative synthetic approaches to one such compound, NVP-DPP728, are investigated here. One strategy is based in solution phase and is amenable to scale-up. The other is based on solid phase and is appropriate for the rapid analoging of the structural series.
1-[2-[(5-Cyanopyridin-2-yl)amino]-ethylamino]acetyl-2-(S)-pyrrolidine -carbonitrile: A potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties
Villhauer, Edwin B.,Brinkman, John A.,Naderi, Goli B.,Dunning, Beth E.,Mangold, Bonnie L.,Mone, Manisha D.,Russell, Mary E.,Weldon, Stephen C.,Hughes, Thomas E.
, p. 2362 - 2365 (2007/10/03)
Dipeptidyl peptidase IV (DPP-IV) inhibition has the potential to become a valuable therapy for type 2 diabetes We report the first use of solid-phase synthesis in the discovery of a new DPP-IV inhibitor class and a solution-phase synthesis that is practical up to the multikilogram scale. One compound NVP-DPP728 (2), is profiled as a potent, selective, and short-acting DPP-IV inhibitor that has excellent oral bioavailability and potent antihyperglycemic activity.
