247068-74-2

Basic information

• Product Name: Fmoc-Ile-Thr-OBn
• Synonyms: Fmoc-Ile-Thr-OBn
• CAS NO: 247068-74-2
• Molecular Weight: 544.648
• Mol File: 247068-74-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Fmoc-Ile-Thr-OBn(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-Ile-Thr-OBn(247068-74-2)
• EPA Substance Registry System: Fmoc-Ile-Thr-OBn(247068-74-2)

Safety Data

• Hazardous Substances Data: 247068-74-2(Hazardous Substances Data)

Upstream product

• 33640-67-4 (2S,3R)-threonine benzyl ester 
• 71989-23-6 Fmoc-Ile-OH 

Downstream Products

• 247068-90-2 (5-{[1-(1-{2-(tert-butyl-diphenyl-silanyloxy)-1-[3-methyl-1-(2-methyl-oxiranecarbonyl)-butylcarbamoyl]-propylcarbamoyl}-2-methyl-butylcarbamoyl)-2-methyl-butyl]-methyl-carbamoyl}-pentyl)-carbamic acid 9H-fluoren-9-ylmethyl ester 
• 247068-88-8 (2S,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-[(2S,3S)-2-((2S,3S)-2-{[6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-methyl-amino}-3-methyl-pentanoylamino)-3-methyl-pentanoylamino]-butyric acid benzyl ester 
• 247068-89-9 (2S,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-[(2S,3S)-2-((2S,3S)-2-{[6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-methyl-amino}-3-methyl-pentanoylamino)-3-methyl-pentanoylamino]-butyric acid 
• 247068-77-5 (2S,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-((2S,3S)-2-{(2S,3S)-2-[(9H-fluoren-9-ylmethoxycarbonyl)-methyl-amino]-3-methyl-pentanoylamino}-3-methyl-pentanoylamino)-butyric acid benzyl ester 
• 247068-86-6 (2S,3S)-2-[(2S,3S)-2-(Acetyl-methyl-amino)-3-methyl-pentanoylamino]-3-methyl-pentanoic acid {(1S,2R)-2-(tert-butyl-diphenyl-silanyloxy)-1-[(S)-3-methyl-1-((R)-2-methyl-oxiranecarbonyl)-butylcarbamoyl]-propyl}-amide 
• 247068-79-7 (2S,3R)-2-{(2S,3S)-2-[(2S,3S)-2-(Acetyl-methyl-amino)-3-methyl-pentanoylamino]-3-methyl-pentanoylamino}-3-(tert-butyl-diphenyl-silanyloxy)-butyric acid benzyl ester 
• 247068-78-6 (2S,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-[(2S,3S)-3-methyl-2-((2S,3S)-3-methyl-2-methylamino-pentanoylamino)-pentanoylamino]-butyric acid benzyl ester 
• 247068-80-0 (2S,3R)-2-{(2S,3S)-2-[(2S,3S)-2-(Acetyl-methyl-amino)-3-methyl-pentanoylamino]-3-methyl-pentanoylamino}-3-(tert-butyl-diphenyl-silanyloxy)-butyric acid 
• 247068-76-4 (2S,3R)-2-((2S,3S)-2-Amino-3-methyl-pentanoylamino)-3-(tert-butyl-diphenyl-silanyloxy)-butyric acid benzyl ester 
• 247068-75-3 (2S,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-[(2S,3S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-pentanoylamino]-butyric acid benzyl ester 

Relevant articles and documents

Total synthesis of the potent proteasome inhibitor epoxomicin: A useful tool for understanding proteasome biology

Epoxomicin (1), a peptide α',β'-epoxyketone isolated from the actinomycete strain No. Q996-17, possesses potent in vivo anti-tumor and anti-inflammatory activities. In this paper, we report the first syntheses of epoxomicin, [3H]-epoxomicin, and a biotinylated epoxomicin analog as well as the absolute configuration of the epoxide stereocenter. The natural product and derivatives have permitted the first identification of the proteasome as the specific cellular target of epoxomicin.