247158-79-8Relevant articles and documents
Pyridazines. Part 28: 5-Alkylidene-6-phenyl-3(2H)-pyridazinones, a new family of platelet aggregation inhibitors
Sotelo, Eddy,Fraiz, Nuria,Yáez, Matilde,Laguna, Reyes,Cano, Ernesto,Brea, José,Ravia, Enrique
, p. 1575 - 1577 (2002)
The synthesis and anti-platelet activity of several 5-alkylidene-6-phenyl-3(2H)-pyridazinones are described. The most active compounds are those that contain oxygenated functions (COOR, COMe) on the alkylidene fragment (6a, 6b and 6c).
Pyridazine derivatives. Part 33: Sonogashira approaches in the synthesis of 5-substituted-6-phenyl-3(2H)-pyridazinones
Coelho, Alberto,Sotelo, Eddy,Ravi?a, Enrique
, p. 2477 - 2484 (2007/10/03)
Several 6-phenyl-3(2H)-pyridazinones bearing different alkynyl groups at position 5 have been prepared by a palladium-catalysed Sonogashira cross-coupling reaction. An interesting base-promoted electronically permitted isomerization has been observed duri
Pyridazines. Part 25: Efficient and selective deprotection of pharmacologically useful 2-MOM-pyridazinones using Lewis acids
Sotelo, Eddy,Coelho, Alberto,Ravi?a, Enrique
, p. 8633 - 8636 (2007/10/03)
An efficient and selective procedure for the cleavage of a methoxymethyl group at the 2-position in acid-sensitive pyridazinones is presented. Deprotection with Lewis acids (boron tribromide or aluminium chloride) affords 3(2H)-pyridazinones under mild co