2472-13-1

Basic information

• Product Name: 6,7-Dimethoxy-2-tetralone
• Synonyms: 6,7-DIMETHOXY-2-TETRALONE;6,7-Dimethoxy-3,4-dihydro-2(1H)-naphthalenone;6,7-dimethoxyl-2-tetralone;6,7-Dimethoxy-3,4-dihydronaphthalen-2(1H)-one;6,7-Dimethoxy-3,4-dihydro-1H-naphthalen-2-one;2(1H)-Naphthalenone,3,4-dihydro-6,7-dimethoxy-
• CAS NO: 2472-13-1
• Molecular Formula: C₁₂H₁₄O₃
• Molecular Weight: 206.24
• Mol File: 2472-13-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 87-89 °C(lit.)
• Boiling Point: 348 °C at 760 mmHg
• Flash Point: 155.5 °C
• Appearance: /
• Density: 1.14 g/cm³
• Vapor Pressure: 5.17E-05mmHg at 25°C
• Refractive Index: 1.537
• CAS DataBase Reference: 6,7-Dimethoxy-2-tetralone(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-Dimethoxy-2-tetralone(2472-13-1)
• EPA Substance Registry System: 6,7-Dimethoxy-2-tetralone(2472-13-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 2472-13-1(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthesis, p. 2033, 1999 DOI: 10.1055/s-1999-3638

InChI:InChI=1/C12H14O3/c1-14-11-6-8-3-4-10(13)5-9(8)7-12(11)15-2/h6-7H,3-5H2,1-2H3

Upstream product

• 153993-01-2 tert-Butyl-[3-(3,4-dimethoxy-phenyl)-1-methylene-propoxy]-dimethyl-silane 
• 74-85-1 ethene 
• 10313-60-7 3,4-dimethoxyphenylacetyl chloride 

Relevant articles and documents

New Intramolecular α-Arylation Strategy of Ketones by the Reaction of Silyl Enol Ethers to Photosensitized Electron Transfer Generated Arene Radical Cations: Construction of Benzannulated and Benzospiroannulated Compounds

Efficient intramolecular α-arylation of ketones is achieved by the reaction of silyl enol ethers to photosensitized electron transfer (PET) generated arene radical cations. The arene radical cations are generated by one-electron transfer from the excited state of the methoxy-substituted arenes to ground-state 1,4-dicyanonaphthalene (DCN). This arylation strategy has provided the unique opportunity of constructing five- (23), six- (18), seven- (25) and eight-membered (27) benzannulated as well as benzospiroannulated (34) compounds. The explanation for the formation of 27 has been advanced by considering the proximity between the arene radical cation and silyl enol ether due to the self-coiling in the aqueous environment.

Spasmolytic Agents. 2. 1,2,3,4-Tetrahydro-2-naphthylamine Derivatives

N--1,2,3,4-tetrahydro-2-naphthylamine derivatives were synthesized from 1,2,3,4-tetrahydro-2-naphthylamines evaluated for their spasmolytic activity.Some of these compounds showed a nerve-selective effect on colon rather than stomach in anesthetized dogs and were found to be equal to or more active than the reference drug (mebeverine).The biological data have indicated some structure-activity relationships.Among these compounds, N-ethyl-N-hexyl>-1,2,3,4-tetrahydro-6-methoxy-2-naphthylamine hydrochloride (63) was found to be the most active spasmolytic agent.