247237-43-0 Usage
Description
5-Chloro-2-[(4-ethoxy-4-oxobutyl)[(4-methylphenyl)sulfonyl]amino]benzoic acid methyl ester is an organic compound with a complex chemical structure. It is characterized by its benzoic acid core, with a methyl ester group attached, a chlorine atom at the 5th position, and a sulfonyl-amino linkage to a 4-methylphenyl group. 5-Chloro-2-[(4-ethoxy-4-oxobutyl)[(4-methylphenyl)sulfonyl]amino]benzoic acid methyl ester is known for its potential applications in the pharmaceutical industry, particularly as a reactant in the synthesis of specific drugs.
Uses
Used in Pharmaceutical Synthesis:
5-Chloro-2-[(4-ethoxy-4-oxobutyl)[(4-methylphenyl)sulfonyl]amino]benzoic acid methyl ester is used as a reactant in the synthesis of Tolvaptan (T536650) and its intermediates. Tolvaptan is a nonpeptide arginine vasopressin (AVP) V2 receptor antagonist, which has various therapeutic applications, particularly in the treatment of autosomal dominant polycystic kidney disease (ADPKD) and hyponatremia.
In the pharmaceutical industry, this compound serves as a key intermediate in the production of Tolvaptan, a drug that helps regulate the balance of water in the body by blocking the effects of arginine vasopressin, a hormone that controls water reabsorption in the kidneys. By inhibiting the V2 receptor, Tolvaptan can increase urine output and reduce the overall volume of the kidneys, providing relief for patients with ADPKD and improving the management of hyponatremia.
Check Digit Verification of cas no
The CAS Registry Mumber 247237-43-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,4,7,2,3 and 7 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 247237-43:
(8*2)+(7*4)+(6*7)+(5*2)+(4*3)+(3*7)+(2*4)+(1*3)=140
140 % 10 = 0
So 247237-43-0 is a valid CAS Registry Number.
247237-43-0Relevant articles and documents
PROCESS FOR PREPARING TOLVAPTAN INTERMEDIATES
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, (2013/07/31)
The present invention provides a novel process for the preparation of 7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one. The present invention also provides an improved process for the preparation of 7-chloro-1-(2-methyl-4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine. The present invention further provides an improved process for the preparation of 7-chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine.
7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5- tetrahydro-1H-1-benzazepine (OPC-41061): A potent, orally active nonpeptide arginine vasopressin V2 receptor antagonist
Kondo, Kazumi,Ogawa, Hidenori,Yamashita, Hiroshi,Miyamoto, Hisashi,Tanaka, Michinori,Nakaya, Kenji,Kitano, Kazuyoshi,Yamamura, Yoshitaka,Nakamura, Shigeki,Onogawa, Toshiyuki,Mori, Toyoki,Tominaga, Michiaki
, p. 1743 - 1754 (2007/10/03)
We previously reported a series of benzazepine derivatives as orally active nonpeptide arginine vasopressin (AVP) V2 receptor antagonists. After the lead structure OPC-31260 was structurally evaluated and optimized, the introduction of the 7-Cl moiety on the benzazepine and 2-CH3 on the aminobenzoyl moiety enhanced its oral activity. The new AVP-V2 selective antagonist OPC-41061 was determined to be a potent and orally active agent. Copyright (C) 1999 Elsevier Science Ltd.