24751-40-4 Usage
General Description
5-N-acetyl-2-O-(3-methoxyphenyl)-alpha-D-neuraminic acid, also known as 3-methoxy-4-hydroxybenzyl ester of N-acetylneuraminic acid, is a synthetic compound that is used in biochemical research and drug development. It is a derivative of sialic acid, which is a key component of many glycoproteins and glycolipids. This chemical has potential therapeutic applications in the treatment of various diseases, including cancer and viral infections. It is also used as a tool in the study of sialic acid metabolism and its role in cellular processes. The unique structural features of 5-N-acetyl-2-O-(3-methoxyphenyl)-alpha-D-neuraminic acid make it a valuable tool for understanding the biological functions of sialic acids and developing new drugs targeting sialic acid-related pathways.
Check Digit Verification of cas no
The CAS Registry Mumber 24751-40-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,7,5 and 1 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 24751-40:
(7*2)+(6*4)+(5*7)+(4*5)+(3*1)+(2*4)+(1*0)=104
104 % 10 = 4
So 24751-40-4 is a valid CAS Registry Number.
InChI:InChI=1/C18H25NO10/c1-9(21)19-14-12(22)7-18(17(25)26,29-16(14)15(24)13(23)8-20)28-11-5-3-4-10(6-11)27-2/h3-6,12-16,20,22-24H,7-8H2,1-2H3,(H,19,21)(H,25,26)/t12-,13+,14+,15+,16+,18+/m0/s1
24751-40-4Relevant articles and documents
PHASE-TRANSFER-CATALYZED SYNTHESIS OF ARYL α-KETOSIDES OF N-ACETYLNEURAMINIC ACID. A 2-METHYLFLUORAN-6-YL GLYCOSIDE OF N-ACETYLNEURAMINIC ACID, 2-METHYL-6-(5-ACETAMIDO-3,5-DIDEOXY-α-D-glycero-D-galacto-NONULOPYRANOSYLONIC ACID)XANTHENE-9-SPIRO-1'-ISOBENZOFURAN-3'-ONE, A NEW SUBSTRATE..
Rothermel, Joerg,Faillard, Hans
, p. 29 - 40 (2007/10/02)
Glycosidation of N-acetylneuraminic acid by phase-transfer catalysis in chloroform-aqueous alkali gave several known and some new aryl α-ketosides in a short reaction time and in good yields.The 4-methylumbelliferyl α-ketoside, the standard substrate for neuraminidase, was prepared in a yield of up to 70percent.New Neu5Ac ketosides were prepared with fluorescein and the fluorescein analog, 2-methyl-6-hydroxyfluoran (2-methyl-6-hydroxyxanthene-9-spiro-1'-isobenzofuran-3'-one) as aglycons, the latter being synthesized from 2-(2-hydroxy-5-methylbenzoyl) benzoic acid and 3-fluorophenol.The α configuration was ascertained by 400-MHz 1H-NMR spectroscopy and by cleavage of the ketosides with neuraminidases from Vibrio cholerae and Clostridium perfringens.The enzymic hydrolysis of the 2-methylfluoran-6-yl ketoside gave Km values of 82 μM (V. cholerae) and 96 μM (C. perfringens).