247569-72-8Relevant articles and documents
Preparation method for 3-chloro-4-methoxybenzylamine hydrochloride
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Paragraph 0003; 0013-0016, (2018/09/08)
The invention discloses a preparation method for 3-chloro-4-methoxybenzylamine hydrochloride. The method uses 4-methoxybenzylamine as a raw material, a reaction is performed with sulfonyl chloride inan acetic acid solvent at room temperature, and recrystallization is performed for purification, wherein a molar ratio of the 4-methoxybenzylamine to the sulfonyl chloride is 1:1.02. The improved method provided by the invention has the characteristics of few by-products, mild reaction conditions, low energy consumption, a high yield and high purity.
Anthranilic acid derivatives as inhibitors of the cGMP-phosphodiesterase
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, (2008/06/13)
Compounds of formula (I) STR1where R 1 is hydrogen; R 2 is nitro, cyano or halo(lower)alkyl; R 3 is phenyl substituted with one or more substituents selected from halogen, cyano and lower alkoxy; A is a lower alkylene group; R 4 is a group CR 6 R 7 R 8 wherein R 6 and R 7 form, together with the carbon atom to which they are attached a cycloalkyl group optionally substituted with hydroxy, lower alkoxy or a lower alkanoylamino; and R 8 is hydrogen; its prodrug and a salt thereof.