247584-10-7

Basic information

• Product Name: 4-AMINO-1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXAMIDE HYDROCHLORIDE
• Synonyms: 1H-Pyrazole-5-carboxaMide,4-aMino-1-Methyl-3-propyl-, hydrochloride (1:1);1H-Pyrazole-5-carboxaMide, 4-aMino-1-Methyl-3-propyl-, hydrochloride;4-AMINO-1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXAMIDE HYDROCHLORIDE;4-AMINO-1-METHYL-3-N-PROPYL-1H-PYRAZOLE-5-CARBOXAMIDE HYDROCHLORIDE;4-Amino-1-Methyl-3-n-Propyl-1H-Pyrazole-5-Carboxamide HCl;1H-Pyrazole-5-carboxamide,4-amino-1-methyl-3-propyl-monohydrochloride;[139756-02-8],C8H14N4O, 182.12;4-amino-1-methyl-3-propyl-,monohydrochloride
• CAS NO: 247584-10-7
• Molecular Formula: C₈H₁₄N₄O*ClH
• Molecular Weight: 218.6839
• EINECS: 1806241-263-5
• Mol File: 247584-10-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 325.9 °C at 760 mmHg
• Flash Point: 150.9 °C
• Appearance: /
• Density: 1.394 g/cm³
• Vapor Pressure: 0.000223mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Aqueous Acid (Slightly)
• CAS DataBase Reference: 4-AMINO-1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXAMIDE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXAMIDE HYDROCHLORIDE(247584-10-7)
• EPA Substance Registry System: 4-AMINO-1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXAMIDE HYDROCHLORIDE(247584-10-7)

Safety Data

• Hazardous Substances Data: 247584-10-7(Hazardous Substances Data)

Usage

Uses

The hydrochloride salt of 4-Amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide, an impurity in the synthesis of Sildenafil.

InChI:InChI=1/C8H14N4O.ClH/c1-3-4-5-6(9)7(8(10)13)12(2)11-5;/h3-4,9H2,1-2H3,(H2,10,13);1H

Synthetic route

1-methyl-4-nitro-3-propyl-1H-pyrazole-5 carboxamide (139756-01-7) + sodium metabisulfite + nickel-Raney catalyst + isopropyl alcohol (67-63-0) → 4-amino-1-methyl-3-n-propylpyrazole-5-carboxamide hydrochloride (247584-10-7)

Conditions	Yield
With hydrazine hydrate In water

4-amino-1-methyl-3-n-propylpyrazole-5-carboxamide hydrochloride (247584-10-7) + 2-bromo-3-thiophene carboxylic acid chloride (197370-13-1) → C13H15BrN4O2S (1072849-26-3)

Conditions	Yield
With triethylamine In pyridine; dichloromethane for 2h; Heating;

Upstream product

• 139756-01-7 1-methyl-4-nitro-3-propyl-1H-pyrazole-5-carboxamide 
• 67-63-0 isopropyl alcohol 

Relevant articles and documents

An improved process for preparing a pyrazolopyrimidinone derivative

An improved process for the preparation of 5-[2-ethoxy-5-(4-methylpiperazin-1-ylsulphonyl)phenyl]-1-methyl-3-n.propyl-1,6-dihydro-7H-pyrazole[4,3-d]pyrimidin-7-one, which allows to obtain the desired product in good yield and high purity degree, is described.