24782-61-4

Basic information

• Product Name: 1-Azabicyclo[2.2.2]octan-3-one, 2-[(4-fluorophenyl)methylene]-
• CAS NO: 24782-61-4
• Molecular Formula: C14H14FNO
• Molecular Weight: 231.27
• Mol File: 24782-61-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-Azabicyclo[2.2.2]octan-3-one, 2-[(4-fluorophenyl)methylene]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Azabicyclo[2.2.2]octan-3-one, 2-[(4-fluorophenyl)methylene]-(24782-61-4)
• EPA Substance Registry System: 1-Azabicyclo[2.2.2]octan-3-one, 2-[(4-fluorophenyl)methylene]-(24782-61-4)

Safety Data

• Hazardous Substances Data: 24782-61-4(Hazardous Substances Data)

Upstream product

• 1193-65-3 3-quinuclidinone hydrochloride 
• 459-57-4 4-fluorobenzaldehyde 
• 3731-38-2 3-Quinuclidinone 

Downstream Products

• 852476-87-0 2-(4-fluorobenzyl)quinuclidin-3-one 
• 24802-69-5 2-(bis(4-fluorophenyl)methyl)quinuclidin-3-one 
• 209863-79-6 2-[1-(4-Fluoro-phenyl)-meth-(E)-ylidene]-1-aza-bicyclo[2.2.2]octan-3-one 

Relevant articles and documents

Aminations and arylations by direct C-O activation for the design of 7,8-dihydro-6H-5,8-ethanopyrido[3,2-d]pyrimidines

The design of some novel disubstituted 7,8-dihydro-6H-5,8-ethanopyrido[3,2-d]pyrimidine derivatives is reported. The series was developed from quinuclidinone, which afforded versatile platforms bearing one lactam function in positionC-2 that were then used to create C-N or C-C bonds for SNAr or palladium-catalyzed cross-coupling reactions byin situC-O activation. The reaction conditions were optimized under microwave irradiation, and a wide range of amines or boronic acids were used to determine the scope and limitations of each method. To complete this study, the X-ray crystallographic data of 7,8-dihydro-6H-5,8-ethanopyrido[3,2-d]pyrimidine derivative49were used to formally establish the structures of the products.

Synthesis and Pharmacological Evaluation of Novel Pyrazolyl Piperidine Derivatives as Effective Antiplatelet Agents

The synthesis and antiplatelet activity of substituted pyrazolyl piperidine derivatives (3a–n) are described. These compounds were synthesized by an improved ring opening reaction of 2-arylidene quinuclidinone using hydrazine hydrate under mild conditions

Mutual Z-/E-isomerization of ferrocenylmethylene- and arylidene-substituted carbo- and heterocycles

The treatment of Z-2-ferrocenylmethylene-, Z-2-arylidene-3-quinuclidinones and 3-methylene-quinuclidines, as well as E-3-ferrocenylmethylenecamphor, -menthone, and -cyclohexanone with NaBPh4 in acetic acid results in their reversible Z-/E-isomerization. The reaction proceeds via hydroxyallyl and crotyl carbocations with a fixed s-cis-conformation.