2479-86-9

Basic information

• Product Name: (3a,5a)Androstan-17-one, 3-(sulfooxy)-,
• Synonyms: (3a,5a)Androstan-17-one, 3-(sulfooxy)-,;Androsterone sulfate
• CAS NO: 2479-86-9
• Molecular Formula: C₁₉H₃₀O₅S
• Molecular Weight: 370.5
• Mol File: 2479-86-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.27g/cm³
• Refractive Index: 1.562
• PKA: -3.48±0.18(Predicted)
• CAS DataBase Reference: (3a,5a)Androstan-17-one, 3-(sulfooxy)-,(CAS DataBase Reference)
• NIST Chemistry Reference: (3a,5a)Androstan-17-one, 3-(sulfooxy)-,(2479-86-9)
• EPA Substance Registry System: (3a,5a)Androstan-17-one, 3-(sulfooxy)-,(2479-86-9)

Safety Data

• Hazardous Substances Data: 2479-86-9(Hazardous Substances Data)

Usage

Definition

ChEBI: A steroid sulfate that is the 3-sulfate of androsterone.

InChI:InChI=1/C19H30O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h12-16H,3-11H2,1-2H3,(H,21,22,23)/t12-,13+,14-,15-,16-,18-,19-/m0/s1

Upstream product

• 53-41-8 cis-androsterone 

Downstream Products

• 53-41-8 cis-androsterone 
• 14639-79-3 5α-androst-2-en-17-one 

Relevant articles and documents

Testosterone sulfotransferase: Evidence in the guinea pig that this reaction is carried out by 3α-hydroxysteroid sulfotransferase

During the course of isolating, characterizing, and cloning estrogen and 3-hydroxysteroid sulfotransferases from the guinea pig adrenal gland, it was noted that cytosolic preparations from this tissue would also sulfonate testosterone. Therefore, we set out to isolate and clone the enzyme that performs this reaction. Testosterone sulfotransferase (TST) was isolated from the guinea pig adrenal by using the standard procedures of ion exchange, affinity, and high-performance liquid chromatography. When purified, TST was examined by liquid-phase nondenaturing isoelectric focusing, it was found that the TST activity profile completely overlapped with the activity profile of the 3α-hydroxysteroid sulfotransferase (3αHST) isoform, but not the 3β-hydroxysteroid sulfotransferase (3βHST) isoform. This finding was further investigated by overexpressing the cDNAs for 3αHST and 3βHST in Escherichia coli and examining the expressed proteins for TST activity. This experiment confirmed that 3αHST does indeed function as a TST. In addition, 3αHST was also found to sulfonate estradiol but not estrone, a finding that further suggested that 3αHST may function as a general 17β-hydroxysteroid sulfotransferase. Copyright (C) 1999.

Steroid conjugates IV. The preparation of steroid sulfates with triethylamine-sulfur trioxide.

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