24805-50-3

Basic information

• Product Name: α-bromo-(3-fluorophenyl)acetic acid
• Synonyms: α-bromo-(3-fluorophenyl)acetic acid
• CAS NO: 24805-50-3
• Molecular Weight: 233.037
• Mol File: 24805-50-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: α-bromo-(3-fluorophenyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: α-bromo-(3-fluorophenyl)acetic acid(24805-50-3)
• EPA Substance Registry System: α-bromo-(3-fluorophenyl)acetic acid(24805-50-3)

Safety Data

• Hazardous Substances Data: 24805-50-3(Hazardous Substances Data)

Upstream product

• 7292-74-2 DL-2-(3-fluorophenyl)glycine 
• 331-25-9 (3-fluorophenyl)acetic acid 

Downstream Products

• 151295-14-6 (2-Chloro-3-fluoro-6-nitro-phenylsulfanyl)-(3-fluoro-phenyl)-acetic acid 
• 251366-58-2 α-bromo-(3-fluorophenyl)acetamide 
• 251366-32-2 2-bromo-2-(p-fluorophenyl)acetamide 
• 151295-24-8 9-Chloro-8-fluoro-2-(3-fluoro-phenyl)-6-oxo-2,3-dihydro-6H-1-thia-3a-aza-phenalene-5-carboxylic acid ethyl ester 
• 151295-17-9 8-Chloro-7-fluoro-2-(3-fluoro-phenyl)-4H-benzo[1,4]thiazin-3-one 
• 151295-20-4 8-Chloro-7-fluoro-2-(3-fluoro-phenyl)-3,4-dihydro-2H-benzo[1,4]thiazine 

Relevant articles and documents

Phthalimide compound as well as preparation method and application thereof

The invention provides a phthalimide compound or a pharmaceutically acceptable salt thereof, wherein the structure of the phthalimide compound is shown as a formula I; in the formula I, R1 is selected from hydrogen, aliphatic hydrocarbon, alkoxy and halogen; R2 and R3 are the same or different and are selected from hydrogen, aliphatic hydrocarbon, alkoxy and halogen; or R2, R3 and connected N atoms are cyclized to form a closed substituted or unsubstituted five-membered or six-membered ring; R1, R2 and R3 can be unsubstituted or substituted by straight chain or branched chain alkyl or alkoxy selected from C1 - C10 and halogen; and R1, R2 and R3 are not hydrogen at the same time. The compound disclosed by the invention has the effect of a ROCK inhibitor and an anti-tumor effect, and is expected to be used as a clinical medicine with a relatively high therapeutic index.

Catalytic Asymmetric Conjugate Addition and Sulfenylation of Diarylthiazolidin-2,4-diones

This work reports the first application of diarylthiazolidin-2,4-diones as nucleophiles in asymmetric catalysis. By utilizing chiral amino acid-based (thio)urea-tertiary amines as the catalysts, we successively established asymmetric conjugate addition to nitroolefins and sulfenylation to N-(sulfanyl)-succinimides of diarylthiazolidin-2,4-diones. Two series of biologically important 5-aryl-5-substituted thiazolidin-2,4-diones were obtained with high enantio- and diastereoselectivities (up to >99% ee and >19:1 dr). The enantioenriched adducts were found to show satisfactory anticancer activities against three different cancer cell lines using the MTT assay. All of these successes depended on the development of a general and expedient synthetic strategy to provide diverse 5H-thiazolidin-2,4-diones.

Quinolinecarboxylic Acids. 3. Synthesis and Antibacterial Evaluation of 2-Substituted-7-oxo-2,3-dihydro-7H-pyridobenzothiazine-6-carboxylic Acids Related to Rufloxacin

A series of 2-substituted-7-oxo-2,3-dihydro-7H-pyridobenzothiazine-6-carboxylic acids has been prepared and evaluated for in vitro antibacterial activity.These derivatives were less active than corresponding desmethylated analogues.Among th