2486-69-3 Usage
Description
4-Amino-3-methoxybenzoic acid is an organic compound characterized by its grey powder form. It is a key building block in the synthesis of various organic compounds, including carbazole alkaloids and (aminophenyl)benzothiazoles, which possess significant biological activities.
Uses
Used in Pharmaceutical Industry:
4-Amino-3-methoxybenzoic acid is used as a key building block for the efficient synthesis of carbazole alkaloids mukonine and mukonidine via oxidative annulation. These alkaloids exhibit various biological activities and are of interest in the development of new pharmaceuticals.
Used in Anticancer Applications:
4-Amino-3-methoxybenzoic acid is used as an intermediate in the preparation of (aminophenyl)benzothiazoles, which have demonstrated antitumor activities. These compounds are being investigated for their potential use in cancer treatment.
Used in Checkpoint Kinase-1 (Chk1) Inhibitors:
4-Amino-3-methoxybenzoic acid is also used to synthesize (phenyl)(cyanopyrazinyl)urea derivatives, which act as Chk1 inhibitors. Chk1 is a protein kinase involved in the regulation of cell cycle progression and DNA repair, and its inhibition is a promising strategy in cancer therapy.
Check Digit Verification of cas no
The CAS Registry Mumber 2486-69-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,4,8 and 6 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2486-69:
(6*2)+(5*4)+(4*8)+(3*6)+(2*6)+(1*9)=103
103 % 10 = 3
So 2486-69-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H9NO3/c1-12-7-4-5(8(10)11)2-3-6(7)9/h2-4H,9H2,1H3,(H,10,11)
2486-69-3Relevant articles and documents
METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION
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Paragraph 0289, (2021/04/02)
Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.
LIGNIN OXIDATION AND PRODUCTS THEREOF
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Page/Page column 83-84, (2012/06/16)
Provided herein is a method of oxidizing lignin. Further disclosed herein are aromatic and non-aromatic compounds obtained from oxidized lignin.