2488-14-4Relevant articles and documents
Synthesis of Imidazole and Histidine-Derived Cross-Linkers as Analogues of GOLD and Desmosine
Sch?del, Nicole,Icik, Esra,Martini, Maike,Altevogt, Luca,Ramming, Isabell,Greulich, Andreas,Baro, Angelika,Bilitewski, Ursula,Laschat, Sabine
supporting information, p. 2260 - 2268 (2021/03/04)
Amino acid derivatives with a central cationic heterocyclic core (e.g., imidazolium) are biologically relevant cross-linkers of proteins and advanced glycation end (AGE) products. Here, imidazolium-containing cross-linkers were synthesized from imidazole or histidine by N-alkylation employing aspartate- and glutamate-derived mesylates as key step. Biological investigations were carried out to probe the biocompatibility of these compounds.
Total Synthesis and Functional Characterization of Selenoneine
Lim, David,Gründemann, Dirk,Seebeck, Florian P.
supporting information, p. 15026 - 15030 (2019/09/12)
The N-α-trimethyl 2-selenohistidine selenoneine is the selenium isolog of the natural antioxidant ergothioneine. Sulfur-to-selenium substitutions are known to endow proteins and nucleic acids with special activities. In contrast, secondary metabolites tha
Allylpalladium(II) histidylidene complexes and their application in Z-selective transfer semihydrogenation of alkynes
Drost, Ruben M.,Broere, Dani?l L. J.,Hoogenboom, Jorin,De Baan, Simone N.,Lutz, Martin,De Bruin,Elsevier
, p. 982 - 996 (2015/03/04)
We have studied the use of amino acid histidine as a precursor for N-heterocyclic carbene (NHC) ligands. This natural amino acid possesses an imidazole substituent, which makes it an interesting NHC precursor that contains both an acid and an amino functi
