248924-06-3

Basic information

• Product Name: (4-METHYL-2-PHENYL-1,3-OXAZOL-5-YL)METHANOL
• Synonyms: (4-METHYL-2-PHENYL-1,3-OXAZOL-5-YL)METHANOL
• CAS NO: 248924-06-3
• Molecular Formula: C₁₁H₁₁NO₂
• Molecular Weight: 189.21
• Mol File: 248924-06-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 361.1±34.0 °C(Predicted)
• Appearance: /
• Density: 1.176±0.06 g/cm3(Predicted)
• PKA: 13.37±0.10(Predicted)
• CAS DataBase Reference: (4-METHYL-2-PHENYL-1,3-OXAZOL-5-YL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (4-METHYL-2-PHENYL-1,3-OXAZOL-5-YL)METHANOL(248924-06-3)
• EPA Substance Registry System: (4-METHYL-2-PHENYL-1,3-OXAZOL-5-YL)METHANOL(248924-06-3)

Safety Data

• Hazardous Substances Data: 248924-06-3(Hazardous Substances Data)

Usage

Description

(4-METHYL-2-PHENYL-1,3-OXAZOL-5-YL)METHANOL is a chemical compound with the molecular formula C12H11NO2. It is a white to off-white solid that is used in various organic synthesis processes. (4-METHYL-2-PHENYL-1,3-OXAZOL-5-YL)METHANOL contains an oxazole ring, which is a five-membered aromatic ring with one oxygen and one nitrogen atom. The presence of a phenyl group contributes to its aromatic nature, and the methyl and methanol groups provide additional functional groups that can participate in chemical reactions.
Used in Pharmaceutical Industry:
(4-METHYL-2-PHENYL-1,3-OXAZOL-5-YL)METHANOL is used as an intermediate in the synthesis of pharmaceutical compounds for its potential therapeutic properties.
Used in Agrochemical Industry:
(4-METHYL-2-PHENYL-1,3-OXAZOL-5-YL)METHANOL is used as a building block in the development of agrochemicals for its potential pesticidal or herbicidal properties.
Used in Academic Research:
(4-METHYL-2-PHENYL-1,3-OXAZOL-5-YL)METHANOL is used as a starting material for the synthesis of more complex molecules in academic research to explore its chemical properties and potential applications.

Upstream product

• 52169-89-8 2-phenyl-4-methyl-oxazole-5-carbonyl chloride 
• 2198-64-3 N-Benzoylalanine 
• 55-21-0 benzamide 
• 22260-83-9 methyl 2-phenyl-4-methyloxazole-5-carboxylate 
• 65-85-0 benzoic acid 
• 4620-46-6 benzoic acid 1-ethoxycarbonyl-2-oxopropyl ester 
• 4620-52-4 Ethyl 4-methyl-2-phenyloxazole-5-carboxylate 

Downstream Products

• 625106-10-7 5-chloromethyl-4-methyl-2-phenyl-oxazole 

Relevant articles and documents

Aromatic heterocyclic small molecule organic compounds and derivatives, preparation method and medical use

The invention discloses heterocyclic aromatic micromolecule organic compounds as shown in the structural formula (I) and derivatives thereof, or hydrates or pharmaceutically acceptable salts, and a preparation method of the corresponding compounds; the invention also discloses an application of the compounds and pharmaceutical compositions containing the compounds to the treatment of various metabolic syndrome-related diseases. The heterocyclic aromatic micromolecule organic compounds of the invention have excellent treatment effect on metabolic syndromes; experiment results show that the compounds may promote secretion of endogenous GLP-1, and are applicable to the preparation of anti-diabetic and fat-reducing candidate medicaments. Aiming at technical problems of easy degradation and short half life of current medicaments for treating diabetes, the invention provides novel, high-efficient micromolecule compounds for promoting secretion of endogenous GLP-1, and the compounds are applicable to the treatment of metabolic syndrome-related diseases such as diabetes, obesity and the like.

Design, synthesis and Structure-activity relationship studies of new thiazole-based free fatty acid receptor 1 agonists for the treatment of type 2 diabetes

The free fatty acid receptor 1 (FFA1/GPR40) has attracted interest as a novel target for the treatment of type 2 diabetes. Several series of FFA1 agonists including TAK-875, the most advanced compound terminated in phase III studies due to concerns about liver toxicity, have been hampered by relatively high molecular weight and lipophilicity. Aiming to develop potent FFA1 agonists with low risk of liver toxicity by decreasing the lipophilicity, the middle phenyl of TAK-875 was replaced by 11 polar five-membered heteroaromatics. Subsequently, systematic exploration of SAR and application of molecular modeling, leads to the identification of compound 44, which was an excellent FFA1 agonist with robustly hypoglycemic effect both in normal and type 2 diabetic mice, low risks of hypoglycemia and liver toxicity even at the twice molar dose of TAK-875. Meanwhile, two important findings were noted. First, the methyl group in our thiazole series occupied a small hydrophobic subpocket which had no interactions with TAK-875. Furthermore, the agonistic activity revealed a good correlation with the dihedral angle between thiazole core and the terminal benzene ring. These results promote the understanding of ligand-binding pocket and might help to design more promising FFA1 agonists.

Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme

Novel thiol derivatives of formula I or of the formula Ia wherein the variables have the meanings as defined hereinbefore.